SLUG anticorps
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- Antigène Voir toutes SLUG (SNAI2) Anticorps
- SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SLUG est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Ascitic fluid
- Immunogène
- Purified recombinant fragment of human SNAI2 expressed in E. Coli.
- Clone
- 2H5
- Isotype
- IgG1
- Top Product
- Discover our top product SNAI2 Anticorps primaire
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- Indications d'application
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Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. - Restrictions
- For Research Use only
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- Format
- Liquid
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
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Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." dans: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).
: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." dans: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, (2008) (PubMed).
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Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." dans: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).
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- Antigène
- SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
- Autre désignation
- SNAI2 (SNAI2 Produits)
- Synonymes
- anticorps Slug, anticorps Slugh, anticorps Snail2, anticorps snail family transcriptional repressor 2, anticorps snail family zinc finger 2, anticorps Snai2
- Sujet
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This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in alpha-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Synonyms: SLUG, WS2D, SLUGH1, MGC10182, SNAI2 - Poids moléculaire
- 30kDa
- ID gène
- 6591
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