Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human TRIM22 (Tripartite motif-containing protein 22)
TRIM22
Reactivité: Humain, Souris
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Restrictions
For Research Use only
Stock
4 °C
Sivaramakrishnan, Sun, Rajmohan, Lin: "B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies." dans: FEBS letters, Vol. 583, Issue 12, pp. 2093-9, (2009) (PubMed).
Eldin, Papon, Oteiza, Brocchi, Lawson, Mechti: "TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus." dans: The Journal of general virology, Vol. 90, Issue Pt 3, pp. 536-45, (2009) (PubMed).
Duan, Gao, Xu, Xiong: "Identification of TRIM22 as a RING finger E3 ubiquitin ligase." dans: Biochemical and biophysical research communications, Vol. 374, Issue 3, pp. 502-6, (2008) (PubMed).
Obad, Brunnström, Vallon-Christersson, Borg, Drott, Gullberg: "Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells." dans: Oncogene, Vol. 23, Issue 23, pp. 4050-9, (2004) (PubMed).
Tissot, Mechti: "Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression." dans: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 14891-8, (1995) (PubMed).
TRIM22 (Tripartite motif-containing protein 22) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a Bbox type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Synonyms: RNF94 (RING finger protein 94), STAF50 (50 kDa-stimulated trans-acting factor)