ITK anticorps (AA 1-26)
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- Antigène Voir toutes ITK Anticorps
- ITK (IL2-Inducible T-Cell Kinase (ITK))
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Épitope
- AA 1-26
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ITK est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Marque
- BD Pharmingen™
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Fusion protein with aa.1-26 of human/mouse Itk
- Clone
- 2F12
- Isotype
- IgG1
- Top Product
- Discover our top product ITK Anticorps primaire
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- Commentaires
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Related Products: ABIN968537
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells." dans: The Journal of experimental medicine, Vol. 187, Issue 10, pp. 1721-7, (1998) (PubMed).
: "Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity." dans: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25401-8, (1997) (PubMed).
: "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11194-8, (1993) (PubMed).
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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells." dans: The Journal of experimental medicine, Vol. 187, Issue 10, pp. 1721-7, (1998) (PubMed).
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- Antigène
- ITK (IL2-Inducible T-Cell Kinase (ITK))
- Autre désignation
- ITK (ITK Produits)
- Sujet
- Itk (IL-2 inducible tyrosine kinase) is a member of the TEC family of intracellular tyrosine kinases. Members of this family are characterized by their role in hematopoietic cell signaling. Itk is expressed primarily in T cells and has been shown to play a role in T-cell antigen receptor (TCR) mediated proliferation, interleukin-2 production, and T cell differentiation. Itk, following stimulation of the TCR becomes phosphorylated on tyrosine 511 by the Src kinase Lck resulting in increased in vitro Itk kinase activity. If phenylalanine is substituted for tyrosine at position 511, the in vivo kinase activity of Itk is drastically diminished, indicating that this site plays a key role in regulating Itk function. Itk migrates at ~72 kDa on SDS/PAGE. (SWISSPROT: Q08881)
- Poids moléculaire
- 72 kDa
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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