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ERBB3 anticorps

ERBB3 Reactivité: Humain WB, IP, IHC (fro), IHC (f) Hôte: Souris Monoclonal RTJ-1 unconjugated
N° du produit ABIN967437
  • Antigène Voir toutes ERBB3 Anticorps
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Reactivité
    • 189
    • 132
    • 117
    • 17
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 191
    • 31
    • 1
    • 1
    Souris
    Clonalité
    • 191
    • 33
    Monoclonal
    Conjugué
    • 110
    • 14
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    Cet anticorp ERBB3 est non-conjugé
    Application
    • 98
    • 70
    • 53
    • 53
    • 51
    • 30
    • 30
    • 23
    • 19
    • 16
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Marque
    BD Pharmingen™
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human c-erbB-3 Peptide
    Clone
    RTJ-1
    Isotype
    IgM
    Top Product
    Discover our top product ERBB3 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Carraway, Cantley: "A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling." dans: Cell, Vol. 78, Issue 1, pp. 5-8, (1994) (PubMed).

    Rajkumar, Gooden, Lemoine, Gullick, Goden: "Expression of the c-erbB-3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1." dans: The Journal of pathology, Vol. 170, Issue 3, pp. 271-8, (1994) (PubMed).

    Sanidas, Filipe, Linehan, Lemoine, Gullick, Rajkumar, Levison: "Expression of the c-erbB-3 gene product in gastric cancer." dans: International journal of cancer. Journal international du cancer, Vol. 54, Issue 6, pp. 935-40, (1993) (PubMed).

    Prigent, Lemoine, Hughes, Plowman, Selden, Gullick: "Expression of the c-erbB-3 protein in normal human adult and fetal tissues." dans: Oncogene, Vol. 7, Issue 7, pp. 1273-8, (1992) (PubMed).

  • Antigène
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Autre désignation
    c-erbB-3 (ERBB3 Produits)
    Synonymes
    anticorps ErbB-3, anticorps HER3, anticorps LCCS2, anticorps MDA-BF-1, anticorps c-erbB-3, anticorps c-erbB3, anticorps erbB3-S, anticorps p180-ErbB3, anticorps p45-sErbB3, anticorps p85-sErbB3, anticorps ERBB3, anticorps C76256, anticorps Erbb-3, anticorps Erbb3r, anticorps Her3, anticorps nuc-ErbB3, anticorps erb-b2 receptor tyrosine kinase 3, anticorps v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), anticorps ERBB3, anticorps Erbb3
    Sujet
    C-erbB-3, a glycoprotein of 160 kD, is a member of the type 1 growth factor receptor subfamily which also includes c-erbB-2 (HER2/neu), c-erbB-4 and the epidermal growth factor receptor (EGFR, c-erbB-1). Members of this receptor subfamily mediate the proliferation and differentiation of normal cells. They have a common structure consisting of an extracellular domain, a transmembrane region, and a cytoplasmic sequence. The extracellular regions contain two cysteine-rich domains, and the intracellular regions have sequence homology to known tyrosine kinases. C-erbB-3 is expressed in tissues from the digestive, urinary and respiratory tracts, the circulatory system, and female and male reproductive organs. c-erb B-3 is undetectable in hematopoietic tissue and cell lines derived from hematopoietic tumors. Cellular localization has been described as cytoplasmic and/or membrane, and nuclear. The level and pattern of c-erbB-3 expression varies widely in both normal and tumor tissues.
    Clone RTJ.1 recognizes an epitope in the cytoplasmic domain of the human c-erbB-3 protein. It does not react with the EGF receptor or c-erbB-2. A synthetic peptide (referred to as 49.3) from the cytoplasmic domain of human c-erbB-3 protein was used as immunogen. RTJ.1 identifies a 160 kD band corresponding to c-erbB-3 by western blot analysis and immunoprecipitation. RTJ.1 may also react with two additional, unidentified higher molecular weight bands by immunoprecipitation and western blot analysis. These bands are likely to be non-specific, as they were not detected with a polyclonal antibody raised against the same immunogen. Because two additional bands were observed, the specificity of RTJ.1 for immunohistochemistry was analyzed by comparing staining results to those obtained using three polyclonal antibodies also raised against 49.3. Identical staining results were obtained using RTJ.1 and all three polyclonal antibodies. These results validated the use of RTJ.1 for immunohistochemical analysis of c-erbB-3.
    Poids moléculaire
    160 kDa
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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