BCAR1 anticorps (pTyr249)
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- Antigène Voir toutes BCAR1 Anticorps
- BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
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Épitope
- pTyr249
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp BCAR1 est non-conjugé
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Application
- Western Blotting (WB)
- Marque
- BD Pharmingen™
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Phosphorylated Human p130Cas
- Clone
- J169-757-12-2
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product BCAR1 Anticorps primaire
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- Commentaires
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Related Products: ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
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Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells." dans: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46533-40, (2003) (PubMed).
: "Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry." dans: Molecular & cellular proteomics : MCP, Vol. 2, Issue 1, pp. 29-36, (2003) (PubMed).
: "
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Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells." dans: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46533-40, (2003) (PubMed).
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- Antigène
- BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
- Autre désignation
- p130 Cas (BCAR1 Produits)
- Synonymes
- anticorps CAS, anticorps CAS1, anticorps CASS1, anticorps CRKAS, anticorps P130Cas, anticorps AI385681, anticorps Cas, anticorps Crkas, anticorps P130CAS, anticorps MGC68466, anticorps cas, anticorps p130cas, anticorps BCAR1, anticorps fc17f11, anticorps wu:fc17f11, anticorps zgc:175192, anticorps BCAR1, Cas family scaffolding protein, anticorps breast cancer anti-estrogen resistance 1, anticorps breast cancer anti-estrogen resistance 1 L homeolog, anticorps breast cancer anti-estrogen resistance protein 1, anticorps BCAR1, anticorps Bcar1, anticorps bcar1.L, anticorps bcar1, anticorps LOC100435586
- Sujet
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P47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. The v-Crk protein is a fusion product of viral Gag protein and a part of cellular Crk that includes SH2 and SH3 domains. v-Crk-induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130Cas (CRK-associated substrate). The p130Cas is tightly associated with v-Crk via the SH2 domain of v-Crk. Tyrosine phosphorylation of p130Cas occurs in conjunction with cellular transformation in cells that express v-Src or v-Crk. This phosphorylation leads to a change in p130Cas localization from the cytoplasm to the cell membrane and, possibly, to the nucleus. Since p130Cas also associates with v-Src, it may be a v-Src substrate. Several phosphorylation sites have been described in p130Cas upon Fibroblast Growth Factor stimulation, and phosphorylated tyrosine (Y249) might function as a binding site for the Crk-adaptor molecule.
The J169-757.12.2 monoclonal antibody recognizes the phosphorylated Y249 of human p130Cas. The orthologous phosphorylation sites in mouse and rat p130Cas are Y253 and Y347, respectively. - Poids moléculaire
- 130 kDa
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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