PDX1 anticorps
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- Antigène Voir toutes PDX1 Anticorps
- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PDX1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI), Intracellular Staining (ICS)
- Marque
- BD Pharmingen™
- Réactivité croisée
- Souris
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Triton is a trademark of the Dow Chemical Company. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human PDX-1 Recombinant Protein
- Clone
- 658A5
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product PDX1 Anticorps primaire
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- Commentaires
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Related Products: ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
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pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis." dans: Developmental biology, Vol. 314, Issue 2, pp. 406-17, (2008) (PubMed).
: "A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis." dans: Molecular genetics and metabolism, Vol. 92, Issue 1-2, pp. 43-55, (2007) (PubMed).
: "Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells." dans: Nature biotechnology, Vol. 24, Issue 11, pp. 1392-401, (2006) (PubMed).
: "Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors." dans: Development (Cambridge, England), Vol. 129, Issue 10, pp. 2447-57, (2002) (PubMed).
: "IPF1, a homeodomain-containing transactivator of the insulin gene." dans: The EMBO journal, Vol. 12, Issue 11, pp. 4251-9, (1993) (PubMed).
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pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis." dans: Developmental biology, Vol. 314, Issue 2, pp. 406-17, (2008) (PubMed).
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- Antigène
- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
- Autre désignation
- PDX-1 (PDX1 Produits)
- Synonymes
- anticorps GSF, anticorps IDX-1, anticorps IPF1, anticorps IUF1, anticorps MODY4, anticorps PDX-1, anticorps STF-1, anticorps ipf1, anticorps PDX1, anticorps IPF-1, anticorps Ipf1, anticorps Mody4, anticorps pdx-1, anticorps Idx1, anticorps Stf1, anticorps zgc:100874, anticorps XlHbox-8, anticorps xlhbox8, anticorps pancreatic and duodenal homeobox 1, anticorps pancreatic and duodenal homeobox 1 S homeolog, anticorps PDX1, anticorps pdx1, anticorps Pdx1, anticorps pdx1.S
- Sujet
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The 658A5 monoclonal antibody binds PDX-1 or Pancreas/Duodenum Homeobox Protein-1 encoded by the PDX1 or IPF1 (Insulin Promoter Factor 1) gene. PDX-1 is a key regulator of pancreatic development and adult beta-cell function. Loss of PDX1 gene function in mice and humans results in pancreatic agenesis. PDX1 is also involved in endocrine precursor cell development by binding the DNA-binding transcription factor Neurogenin 3. PDX-1 positive cells have been obtained by the directed differentiation of human embryonic stem cells through a definitive endoderm lineage.
Synonyms: PDX1, GSF, IPF-1, IPF1, IUF-1, IDX-1, STF-1 - Poids moléculaire
- 40 kDa
- ID gène
- 3651
- Pathways
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
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