FGF2 anticorps (AA 1-155)

N° du produit ABIN967725

Détail du produit anti-FGF2 anticorps

Antigène: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Épitope: AA 1-155

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FGF2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Réactivité croisée: Souris, Rat (Rattus), Chien, Poulet

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human bFGF aa. 1-155

Clone: 6-basic FGF

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-FGF2 (ABIN967725)

Yaccoby, Johnson, Mahaffey, Wezeman, Barlogie, Epstein: "Antimyeloma efficacy of thalidomide in the SCID-hu model." dans: Blood, Vol. 100, Issue 12, pp. 4162-8, (2002) (PubMed).

Peng, Moffett, Myers, Fang, Stachowiak, Maher, Kratz, Hines, Fluharty, Mizukoshi, Bloom, Stachowiak: "Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors." dans: Molecular biology of the cell, Vol. 12, Issue 2, pp. 449-62, (2001) (PubMed).

Estival, Monzat, Miquel, Gaubert, Hollande, Korc, Vaysse, Clemente: "Differential regulation of fibroblast growth factor (FGF) receptor-1 mRNA and protein by two molecular forms of basic FGF. Modulation of FGFR-1 mRNA stability." dans: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5663-70, (1996) (PubMed).

Fox, Shanley: "Antisense inhibition of basic fibroblast growth factor induces apoptosis in vascular smooth muscle cells." dans: The Journal of biological chemistry, Vol. 271, Issue 21, pp. 12578-84, (1996) (PubMed).

Stachowiak, Moffett, Joy, Puchacz, Florkiewicz, Stachowiak: "Regulation of bFGF gene expression and subcellular distribution of bFGF protein in adrenal medullary cells." dans: The Journal of cell biology, Vol. 127, Issue 1, pp. 203-23, (1994) (PubMed).

Détails sur FGF2

Antigène: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Autre désignation: basic FGF (FGF2 Produits)

Synonymes: anticorps BFGF, anticorps FGF-2, anticorps FGFB, anticorps HBGF-2, anticorps Fgf-2, anticorps Fgfb, anticorps bFGF, anticorps fibroblast growth factor 2, anticorps fibroblast growth factor 2 (basic), anticorps FGF2, anticorps Fgf2, anticorps fgf2

Sujet: Basic Fibroblast Growth Factor (bFGF) is a family member of the cell-differentiating and growth promoting factors. Basic FGF exists as multiple isoforms ranging from 18-24kDa that are derived from a single mRNA species under unique translational conditions. The 18kDa isoform is primarily cytosolic, but is also secreted and may form reservoirs of bFGF in the extracellular matrix. In contrast, the larger isoforms are predominantly nuclear. At the cellular level, bFGF is a potent mitogen and promotes cell survival by inhibiting apoptosis. At the tissue level, it is involved in wound repair and induces angiogenesis. In addition, bFGF is a significant target in cancer research because it is over-expressed in some cancers and may enhance a tumor's metastatic potential.

Poids moléculaire: 18-24 kDa

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteins