SHP1 anticorps (AA 492-597)

N° du produit ABIN967767

Détail du produit anti-SHP1 anticorps

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Épitope: AA 492-597

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SHP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Chien, Rat (Rattus), Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human PTP1C aa.. 492-597

Clone: 52-PTP1C-SHP1

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-SHP1 (ABIN967767)

Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." dans: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, (2002) (PubMed).

Keilhack, Müller, Böhmer, Frank, Weidner, Birchmeier, Ligensa, Berndt, Kosmehl, Günther, Müller, Birchmeier, Böhmer: "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1." dans: The Journal of cell biology, Vol. 152, Issue 2, pp. 325-34, (2001) (PubMed).

Lund-Johansen, Davis, Bishop, de Waal Malefyt: "Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions." dans: Cytometry, Vol. 39, Issue 4, pp. 250-9, (2000) (PubMed).

Liu, Hill, Chernoff: "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)." dans: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31290-5, (1997) (PubMed).

Kenner, Anyanwu, Olefsky, Kusari: "Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling." dans: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19810-6, (1996) (PubMed).

Détails sur SHP1

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Autre désignation: PTP1C (PTPN6 Produits)

Synonymes: anticorps HCPH, anticorps HPTP1C, anticorps PTP-1C, anticorps SH-PTP1, anticorps SHP-1, anticorps SHP-1L, anticorps SHP1, anticorps DRPLA, anticorps Hcph, anticorps Ptp1C, anticorps me, anticorps motheaten, anticorps Ptph6, anticorps Shp-1, anticorps fj22f05, anticorps wu:fj22f05, anticorps zgc:55501, anticorps ptpn6, anticorps protein tyrosine phosphatase, non-receptor type 6, anticorps protein tyrosine phosphatase, non-receptor type 6 L homeolog, anticorps PTPN6, anticorps Ptpn6, anticorps ptpn6, anticorps ptpn6.L

Sujet: PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.

Poids moléculaire: 68 kDa

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling