FAS anticorps (AA 1-163)
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- Antigène Voir toutes FAS Anticorps
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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Épitope
- AA 1-163
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Reactivité
- Humain, Rat, Souris, Chien, Poulet
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FAS est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Réactivité croisée
- Poulet, Chien, Souris, Rat (Rattus)
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human Fas aa. 1-163
- Clone
- 13-Fas
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product FAS Anticorps primaire
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- Commentaires
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Related Products: ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
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Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells." dans: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37273-9, (2001) (PubMed).
: "Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation." dans: Oncogene, Vol. 20, Issue 46, pp. 6764-76, (2001) (PubMed).
: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." dans: Oncogene, Vol. 19, Issue 51, pp. 5906-18, (2000) (PubMed).
: "Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7140-7, (1999) (PubMed).
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Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells." dans: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37273-9, (2001) (PubMed).
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- Antigène
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Autre désignation
- CD95 (FAS Produits)
- Synonymes
- anticorps ALPS1A, anticorps APO-1, anticorps APT1, anticorps CD95, anticorps FAS1, anticorps FASTM, anticorps TNFRSF6, anticorps AI196731, anticorps APO1, anticorps TNFR6, anticorps Tnfrsf6, anticorps lpr, anticorps Fas cell surface death receptor, anticorps Fas (TNF receptor superfamily member 6), anticorps FAS, anticorps Fas, anticorps fas
- Sujet
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CD95 is a member of a family of cell surface receptors that includes tumor necrosis factor receptor (TNF-R), nerve growth factor receptor (NGF-R), CD40, CD27, CD30, and 4-1BB. Both murine and human Fas genes have been cloned and reportedly share 60% similarity in their amino acid sequences. CD95 (Fas) is a cell surface apoptosis-signaling molecule that is widely expressed in sites such as thymus, liver, heart, and ovary. Abnormalities in the Fas gene correlate with autoimmune features in mice and with unusually high levels of lymphocyte apoptosis in HIV-infected humans. Genetic studies have localized the Fas gene near the lpr (lymphoproliferation disease) locus on mouse chromosome 19 and further characterization reportedly has revealed that lpr is a mutation affecting the function of the Fas gene. This antibody is routinely tested by western blot analysis.
Synonyms: Fas, APO-1 - Poids moléculaire
- 45 kDa
- Pathways
- Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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