JAK1 anticorps (AA 551-766)

N° du produit ABIN967842

Détail du produit anti-JAK1 anticorps

Antigène: JAK1 (Janus Kinase 1 (JAK1))

Épitope: AA 551-766

Reactivité: Humain, Souris, Rat, Poulet, Chien, Grenouille

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JAK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Chien, Rat (Rattus), Souris, Poulet, Grenouille

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human JAK1 aa. 551-766

Clone: 73-JAK1

Isotype: IgG1 kappa

Information d'application

Commentaires:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-JAK1 (ABIN967842)

Kopantzev, Heller, Swaminathan, Rudikoff: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." dans: Oncogene, Vol. 21, Issue 44, pp. 6791-800, (2002) (PubMed).

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." dans: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).

Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." dans: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, (2001) (PubMed).

Müller, Briscoe, Laxton, Guschin, Ziemiecki, Silvennoinen, Harpur, Barbieri, Witthuhn, Schindler: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." dans: Nature, Vol. 366, Issue 6451, pp. 129-35, (1993) (PubMed).

Détails sur JAK1

Antigène: JAK1 (Janus Kinase 1 (JAK1))

Autre désignation: JAK1 (JAK1 Produits)

Synonymes: anticorps JAK1A, anticorps JAK1B, anticorps JTK3, anticorps AA960307, anticorps C130039L05Rik, anticorps wu:fb93e10, anticorps jak1, anticorps Janus kinase 1, anticorps tyrosine-protein kinase JAK1, anticorps JAK1, anticorps Jak1, anticorps jak1, anticorps LOC100286690

Sujet: The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.

Poids moléculaire: 130 kDa

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response