BCAR1 anticorps (AA 644-819)

N° du produit ABIN967872

Détail du produit anti-BCAR1 anticorps

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Épitope: AA 644-819

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCAR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Réactivité croisée: Humain, Poulet, Chien, Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat p130 [Cas] aa. 644-819

Clone: 21-p130[Cas]

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-BCAR1 (ABIN967872)

Hermanto, Zong, Li, Wang: "RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix." dans: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2345-65, (2002) (PubMed).

Nagashima, Endo, Ogita, Kawana, Yamagishi, Kitabatake, Matsuda, Mochizuki: "Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells." dans: Molecular biology of the cell, Vol. 13, Issue 12, pp. 4231-42, (2002) (PubMed).

Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: "Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus." dans: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38289-96, (2001) (PubMed).

Kook, Shim, Choi, Ahnn, Kim, Eom, Jung, Paik, Song: "Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells." dans: Molecular biology of the cell, Vol. 11, Issue 3, pp. 929-39, (2000) (PubMed).

Sakai, Iwamatsu, Hirano, Ogawa, Tanaka, Mano, Yazaki, Hirai: "A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner." dans: The EMBO journal, Vol. 13, Issue 16, pp. 3748-56, (1994) (PubMed).

Détails sur BCAR1

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Autre désignation: p130 Cas (BCAR1 Produits)

Synonymes: anticorps CAS, anticorps CAS1, anticorps CASS1, anticorps CRKAS, anticorps P130Cas, anticorps AI385681, anticorps Cas, anticorps Crkas, anticorps P130CAS, anticorps MGC68466, anticorps cas, anticorps p130cas, anticorps BCAR1, anticorps fc17f11, anticorps wu:fc17f11, anticorps zgc:175192, anticorps BCAR1, Cas family scaffolding protein, anticorps breast cancer anti-estrogen resistance 1, anticorps breast cancer anti-estrogen resistance 1 L homeolog, anticorps breast cancer anti-estrogen resistance protein 1, anticorps BCAR1, anticorps Bcar1, anticorps bcar1.L, anticorps bcar1, anticorps LOC100435586

Sujet: P47 [v-crk] is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. The v-crk protein is a fusion product of the viral gag protein and a part of cellular crk that includes SH2 and SH3 domains. v-crk induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130 [Cas]. p130 [Cas] is tightly associated with v-crk via the SH2 domain of v-crk. Tyrosine phosphorylation of p130 [Cas] occurs in conjunction with cellular transformation in cells that express v-src or v-crk. This phosphorylation leads to a change in p130 [Cas] localization from the cytoplasm to the cell membrane and, possibly, to the nucleus. Since p130 [Cas] also associates with v-src, it may be a v-src substrate. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 130 kDa

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling