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BDKRB2 anticorps (AA 350-364)

BDKRB2 Reactivité: Humain, Rat WB, IHC, IF, IP Hôte: Souris Monoclonal 20-B2 Bradykinin Receptor unconjugated
N° du produit ABIN967978
  • Antigène Voir toutes BDKRB2 Anticorps
    BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
    Épitope
    • 16
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 350-364
    Reactivité
    • 35
    • 32
    • 20
    • 2
    Humain, Rat
    Hôte
    • 46
    • 3
    Souris
    Clonalité
    • 39
    • 10
    Monoclonal
    Conjugué
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BDKRB2 est non-conjugé
    Application
    • 31
    • 18
    • 13
    • 13
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human B2 Bradykinin Receptor aa. 350-364
    Clone
    20-B2 Bradykinin Receptor
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product BDKRB2 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Ewert, Johansson, Holm, Helander, Fandriks: "The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion." dans: BMC physiology, Vol. 3, pp. 1, (2003) (PubMed).

    Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." dans: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, (2002) (PubMed).

    Xie, Browning, Hay, Mackman, Ye: "Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt." dans: The Journal of biological chemistry, Vol. 275, Issue 32, pp. 24907-14, (2000) (PubMed).

    Golser, Gorren, Leber, Andrew, Habisch, Werner, Schmidt, Venema, Mayer: "Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation." dans: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5291-6, (2000) (PubMed).

    Powell, Slynn, Thomas, Hopkins, Briggs, Graham: "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14." dans: Genomics, Vol. 15, Issue 2, pp. 435-8, (1993) (PubMed).

  • Antigène
    BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
    Autre désignation
    B2 Bradykinin Receptor (BDKRB2 Produits)
    Synonymes
    anticorps BDKRB2, anticorps b2r, anticorps bk2, anticorps bk-2, anticorps bkr2, anticorps brb2, anticorps kinrec, anticorps B2R, anticorps BK-2, anticorps BK2, anticorps BKR2, anticorps BRB2, anticorps B2BKR, anticorps B2BRA, anticorps B(2), anticorps B2, anticorps BK2R, anticorps Bdkrb2, anticorps bradykinin receptor B2, anticorps bradykinin receptor, beta 2, anticorps bradykinin type 2 receptor, anticorps Bdkrb2, anticorps BDKRB2, anticorps bdkrb2, anticorps kinrec, anticorps B2R
    Sujet
    Bradykinin is a nine amino acid vasoactive peptide that elicits numerous physiologic responses such as vasodilation, smooth muscle spasm, and pain. Bradykinin is one of a family of such peptides called the kinins. The kinins are generated from high molecular weight precursors called kininogens from proteolysis induced by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are mediated by their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes: B1 and B2. Both are coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas, the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven helix G-protein coupled receptors. Bradykinin has a relatively low affinity for B1 receptors, and interacts primarily with the B2 receptor. This interaction stimulates several second messenger systems, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.
    Poids moléculaire
    42 kDa
    Pathways
    ACE Inhibitor Pathway, Negative Regulation of intrinsic apoptotic Signaling
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