NUP62 anticorps (AA 24-178)

N° du produit ABIN968005

Détail du produit anti-NUP62 anticorps

Antigène: NUP62 (Nucleoporin 62kDa (NUP62))

Épitope: AA 24-178

Reactivité: Humain, Souris, Rat, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUP62 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Poulet, Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Nucleoporin aa. 24-178

Clone: 53-Nucleoporin p62

Isotype: IgG2b

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-NUP62 (ABIN968005)

Paroni, Henderson, Schneider, Brancolini: "Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus." dans: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 15147-61, (2002) (PubMed).

Shah, Patel, Fried, Sehgal: "Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever." dans: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45662-9, (2002) (PubMed).

Daigle, Beaudouin, Hartnell, Imreh, Hallberg, Lippincott-Schwartz, Ellenberg: "Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells." dans: The Journal of cell biology, Vol. 154, Issue 1, pp. 71-84, (2001) (PubMed).

Iborra, Jackson, Cook: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." dans: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).

Carmo-Fonseca, Kern, Hurt: "Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization." dans: European journal of cell biology, Vol. 55, Issue 1, pp. 17-30, (1991) (PubMed).

Détails sur NUP62

Antigène: NUP62 (Nucleoporin 62kDa (NUP62))

Autre désignation: Nucleoporin p62 (NUP62 Produits)

Synonymes: anticorps IBSN, anticorps SNDI, anticorps p62, anticorps NUP62, anticorps AA589433, anticorps AI426861, anticorps AI790512, anticorps AU045898, anticorps D7Ertd649e, anticorps Nupc1, anticorps CG6251, anticorps Dmel\\CG6251, anticorps DDBDRAFT_0167902, anticorps DDBDRAFT_0237712, anticorps DDB_0167902, anticorps DDB_0237712, anticorps nup62, anticorps Np62, anticorps nucleoporin 62, anticorps hypothetical protein, anticorps nucleoporin 62kDa, anticorps Nucleoporin 62kD, anticorps predicted protein, anticorps nuclear pore protein, anticorps Nup62 nuclear pore complex glycoprotein p62-related protein (IC), anticorps Nuclear pore glycoprotein p62, anticorps NUP62, anticorps PGTG_03077, anticorps Nup62, anticorps nup62

Sujet: The nuclear pore complex (NPC) acts as a gate to mediate active transport of proteins and RNA into and out of the nucleus. Proteins actively transported into the nucleus through the NPC require specific nuclear localization sequences. Many of these nucleoporins contain N-acetylglucosamine (GlcNAc) residues that are O-linked to serine or threonine. p62 is the best characterized member of a group of nucleoporins that line the central region of the NPC. A tightly associated complex is formed by p62 and two other nucleoporins, p54 and p58. p54 binds to a carboxy-terminal coiled-coil domain of p62 and p58 binds to a dimer of p54. The amino-terminal domain of p62 contains a series of XFXFX repeats and is joined to the coiled-coil domain by a threonine-rich linker segment. The major role of p62 is maintenance of the structural integrity of NPCs.

Poids moléculaire: 62 kDa

Pathways: EGFR Signaling Pathway, SARS-CoV-2 Protein Interactome