NUMA1 anticorps (AA 10-189)

N° du produit ABIN968039

Détail du produit anti-NUMA1 anticorps

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Épitope: AA 10-189

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUMA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Souris, Rat (Rattus), Poulet, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human NuMA aa. 10-189

Clone: 22-NuMA

Isotype: IgM

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-NUMA1 (ABIN968039)

Elbi, Misteli, Hager: "Recruitment of dioxin receptor to active transcription sites." dans: Molecular biology of the cell, Vol. 13, Issue 6, pp. 2001-15, (2002) (PubMed).

Munnia, Schütz, Romeike, Maldener, Glass, Maas, Nastainczyk, Feiden, Fischer, Meese: "Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor." dans: Oncogene, Vol. 20, Issue 35, pp. 4853-63, (2001) (PubMed).

Steen, Cubizolles, Le Guellec, Collas: "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract." dans: The Journal of cell biology, Vol. 149, Issue 3, pp. 531-6, (2000) (PubMed).

Yang, Lambie, Snyder: "NuMA: an unusually long coiled-coil related protein in the mammalian nucleus." dans: The Journal of cell biology, Vol. 116, Issue 6, pp. 1303-17, (1992) (PubMed).

Détails sur NUMA1

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Autre désignation: NuMA (NUMA1 Produits)

Synonymes: anticorps NUMA, anticorps 6720401E04Rik, anticorps AA764025, anticorps AL022610, anticorps AU014979, anticorps NUMA1, anticorps NuMA, anticorps SP-H, anticorps numa, anticorps numa1, anticorps nuclear mitotic apparatus protein 1, anticorps nuclear mitotic apparatus protein 1 S homeolog, anticorps NUMA1, anticorps Numa1, anticorps numa1, anticorps numa1.S

Sujet: NuMA (Nuclear Mitotic Apparatus protein) is a 2115 amino acid protein with a coiled-coil structure similar to that of myosins and intermediate filaments. Indirect immunofluorescence assays indicate that NuMA's localization is very dynamic. During interphase, NuMA is in the nucleus and during mitosis it moves to the polar regions of the mitotic spindle. NuMA is a very abundant phosphoprotein and antibodies to this protein are often found in patients with autoimmune diseases. Although NuMA is thought to be a structural component of the nucleus, the precise cellular function for this protein is still unknown.

Poids moléculaire: 238-290 kDa

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase