SNRPN anticorps (AA 14-174)

N° du produit ABIN968086

Détail du produit anti-SNRPN anticorps

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Épitope: AA 14-174

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNRPN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Réactivité croisée: Souris, Rat (Rattus), Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human SMN aa. 14-174

Clone: 8-SMN

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968587, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-SNRPN (ABIN968086)

Briese, Richter, Sattelle, Ulfig: "SMN, the product of the spinal muscular atrophy-determining gene, is expressed widely but selectively in the developing human forebrain." dans: The Journal of comparative neurology, Vol. 497, Issue 5, pp. 808-16, (2006) (PubMed).

Côté, Boisvert, Boulanger, Bedford, Richard: "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1." dans: Molecular biology of the cell, Vol. 14, Issue 1, pp. 274-87, (2003) (PubMed).

Claus, Doring, Gringel, Muller-Ostermeyer, Fuhlrott, Kraft, Grothe: "Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein." dans: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 479-85, (2002) (PubMed).

Wang, Reddy, Shen: "Higher order arrangement of the eukaryotic nuclear bodies." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13583-8, (2002) (PubMed).

Cifuentes-Diaz, Frugier, Tiziano, Lacène, Roblot, Joshi, Moreau, Melki: "Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy." dans: The Journal of cell biology, Vol. 152, Issue 5, pp. 1107-14, (2001) (PubMed).

Lefebvre, Bürglen, Reboullet, Clermont, Burlet, Viollet, Benichou, Cruaud, Millasseau, Zeviani: "Identification and characterization of a spinal muscular atrophy-determining gene." dans: Cell, Vol. 80, Issue 1, pp. 155-65, (1995) (PubMed).

Détails sur SNRPN

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Autre désignation: SMN (SNRPN Produits)

Synonymes: anticorps SNRB', anticorps SNRPB', anticorps Snrpn, anticorps zgc:77315, anticorps HCERN3, anticorps PWCR, anticorps RT-LI, anticorps SM-D, anticorps SMN, anticorps SNRNP-N, anticorps SNURF-SNRPN, anticorps sm-N, anticorps 2410045I01Rik, anticorps Peg4, anticorps Pwcr1, anticorps FE 294, anticorps FE 294 psi, anticorps FE294, anticorps FE294 psi, anticorps SNURF, anticorps SNRPN, anticorps QflA-11237, anticorps QtrA-10022, anticorps Sm-N, anticorps SmN, anticorps snRNP-N, anticorps small nuclear ribonucleoprotein polypeptide-like, anticorps small nuclear ribonucleoprotein polypeptides B and B1, anticorps small nuclear ribonucleoprotein polypeptide N, anticorps small nuclear ribonucleoprotein N, anticorps small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51, anticorps SNRPN upstream reading frame, anticorps Small nuclear ribonucleoprotein-associated protein N, anticorps SNRPL, anticorps snrpb, anticorps SNRPN, anticorps Snrpn, anticorps snrpn, anticorps SNURF

Sujet: SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40 kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0 µm within the nucleus. These novel nuclear structures were named gems and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.
Synonyms: Survival Motor Neuron

Poids moléculaire: 40 kDa