XIAP anticorps (AA 268-426)

N° du produit ABIN968133

Détail du produit anti-XIAP anticorps

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Épitope: AA 268-426

Reactivité: Humain, Souris, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XIAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Chien, Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human hILP/XIAP aa. 268-426

Clone: 28-hILP-XIAP

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-XIAP (ABIN968133)

Birkey Reffey, Wurthner, Parks, Roberts, Duckett: "X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling." dans: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 26542-9, (2001) (PubMed).

Lee, Shacter: "Fas aggregation does not correlate with Fas-mediated apoptosis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 82-9, (2001) (PubMed).

Wang, Gastman, Wieckowski, Goldstein, Rabinovitz, Yin, Rabinowich: "Apoptosis-resistant mitochondria in T cells selected for resistance to Fas signaling." dans: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3610-9, (2001) (PubMed).

Yang, Fang, Jensen, Weissman, Ashwell: "Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli." dans: Science (New York, N.Y.), Vol. 288, Issue 5467, pp. 874-7, (2000) (PubMed).

Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." dans: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, (1996) (PubMed).

Détails sur XIAP

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Autre désignation: hILP (XIAP Produits)

Synonymes: anticorps API3, anticorps BIRC4, anticorps IAP-3, anticorps ILP1, anticorps MIHA, anticorps XLP2, anticorps hIAP-3, anticorps hIAP3, anticorps api3, anticorps birc4, anticorps ilp1, anticorps miha, anticorps xlp2, anticorps xxiap, anticorps 1110015C02Rik, anticorps Aipa, anticorps Api3, anticorps Birc4, anticorps IAP3, anticorps ILP-1, anticorps mXIAP, anticorps riap3, anticorps fb73d01, anticorps wu:fb73d01, anticorps zgc:91873, anticorps BIRC8, anticorps X-linked inhibitor of apoptosis, anticorps X-linked inhibitor of apoptosis L homeolog, anticorps XIAP, anticorps xiap, anticorps xiap.L, anticorps Xiap

Sujet: Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
Synonyms: hILP

Poids moléculaire: 57 kDa

Pathways: Apoptose, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis