PAX5 anticorps (AA 151-306)

N° du produit ABIN968220

Détail du produit anti-PAX5 anticorps

Antigène: PAX5 (Paired Box 5 (PAX5))

Épitope: AA 151-306

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Pax-5 aa. 151-306

Clone: 24-Pax

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968544, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-PAX5 (ABIN968220)

Klein, Tu, Stolovitzky, Keller, Haddad, Miljkovic, Cattoretti, Califano, Dalla-Favera: "Transcriptional analysis of the B cell germinal center reaction." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2639-44, (2003) (PubMed).

Hertel, Zhou, Hamilton-Dutoit, Junker: "Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma." dans: Oncogene, Vol. 21, Issue 32, pp. 4908-20, (2002) (PubMed).

Foss, Reusch, Demel, Lenz, Anagnostopoulos, Hummel, Stein: "Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin." dans: Blood, Vol. 94, Issue 9, pp. 3108-13, (1999) (PubMed).

Zwollo, Arrieta, Ede, Molinder, Desiderio, Pollock: "The Pax-5 gene is alternatively spliced during B-cell development." dans: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10160-8, (1997) (PubMed).

Adams, Dörfler, Aguzzi, Kozmik, Urbánek, Maurer-Fogy, Busslinger: "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis." dans: Genes & development, Vol. 6, Issue 9, pp. 1589-607, (1992) (PubMed).

Détails sur PAX5

Antigène: PAX5 (Paired Box 5 (PAX5))

Autre désignation: Pax-5 (PAX5 Produits)

Synonymes: anticorps PAX5, anticorps BSAP, anticorps Pax-5, anticorps pax5-a, anticorps RGD1565236, anticorps EBB-1, anticorps KLP, anticorps Pax[Zf-b], anticorps noi, anticorps pax2.1, anticorps pax2a, anticorps paxzf-b, anticorps paired box 5, anticorps paired box 5 L homeolog, anticorps PAX5, anticorps pax5.L, anticorps Pax5, anticorps pax5

Sujet: There are at least nine members of the paired box (Pax) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied Pax family members, Pax 5, is a B cell specific activator protein (BSAP). In the early stages of B cell development, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. Pax-5 has been found to be important in both B cell and nervous system development. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 50 kDa