TRAF4 anticorps (AA 2-160)

N° du produit ABIN968221

Détail du produit anti-TRAF4 anticorps

Antigène: TRAF4 (TNF Receptor-Associated Factor 4 (TRAF4))

Épitope: AA 2-160

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TRAF4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Chien, Rat (Rattus), Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human CART1 aa. 2-160

Clone: 43-TRAF4

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-TRAF4 (ABIN968221)

Bièche, Tomasetto, Régnier, Moog-Lutz, Rio, Lidereau: "Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer." dans: Cancer research, Vol. 56, Issue 17, pp. 3886-90, (1996) (PubMed).

Régnier, Tomasetto, Moog-Lutz, Chenard, Wendling, Basset, Rio: "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma." dans: The Journal of biological chemistry, Vol. 270, Issue 43, pp. 25715-21, (1995) (PubMed).

Détails sur TRAF4

Antigène: TRAF4 (TNF Receptor-Associated Factor 4 (TRAF4))

Autre désignation: TRAF4 (TRAF4 Produits)

Synonymes: anticorps CART1, anticorps MLN62, anticorps RNF83, anticorps A530032M13Rik, anticorps msp2, anticorps traf4, anticorps cart1, anticorps mln62, anticorps rnf83, anticorps traf-4, anticorps traf4l, anticorps zgc:77418, anticorps TNF receptor associated factor 4, anticorps Tnf receptor associated factor 4, anticorps tnf receptor-associated factor 4b, anticorps TNF receptor associated factor 4 L homeolog, anticorps tnf receptor-associated factor 4a, anticorps TRAF4, anticorps Traf4, anticorps traf4b, anticorps traf4.L, anticorps traf4a

Sujet: CART1 gene, located on q11-q12 region of the chromosome 17 long arm, is commonly amplified in human breast carcinomas. The CART1 protein contains several motifs known as the RING, CART, and TRAF domains. The RING domain is cysteine rich (C3HC3D) and is located at the N-terminus. The CART domain is centrally located in the protein and is a cysteine-rich region composed of three repeats of HC3HC3. The TRAF domain is located at the C-terminus and is involved in protein-protein interactions. These domains are also found in the human CD40-binding protein and the mouse TNF receptor-associated factor 2 (TRAF2), which are involved in TNF receptor signaling pathways. CART1 is also known as TRAF4 and is a member of the TRAF family of proteins. TRAF4/CART1 is expressed in breast carcinomas and metastatic axillary lymph nodes, while the mRNA is found in malignant epithelial cells. Immunohistochemistry of a breast carcinoma revealed that TRAF4 is located within the nucleus. Therefore, TRAF4 may play a role in the development of breast carcinomas via TNF-dependent signaling pathways.

Poids moléculaire: 53 kDa