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Utrophin anticorps (AA 768-874)

UTRN Reactivité: Souris WB, IF Hôte: Souris Monoclonal 55-Utrophin unconjugated
N° du produit ABIN968237
  • Antigène Voir toutes Utrophin (UTRN) Anticorps
    Utrophin (UTRN)
    Épitope
    • 2
    • 1
    AA 768-874
    Reactivité
    • 17
    • 13
    • 13
    Souris
    Hôte
    • 14
    • 3
    Souris
    Clonalité
    • 15
    • 2
    Monoclonal
    Conjugué
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Utrophin est non-conjugé
    Application
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse Utrophin aa. 768-874
    Clone
    55-Utrophin
    Isotype
    IgG1
    Top Product
    Discover our top product UTRN Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Gramolini, Burton, Tinsley, Ferns, Cartaud, Cartaud, Davies, Lunde, Jasmin: "Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism." dans: The Journal of biological chemistry, Vol. 273, Issue 2, pp. 736-43, (1998) (PubMed).

    Deconinck, Rafael, Skinner, Brown, Potter, Metzinger, Watt, Dickson, Tinsley, Davies: "Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy." dans: Cell, Vol. 90, Issue 4, pp. 717-27, (1997) (PubMed).

    Grady, Teng, Nichol, Cunningham, Wilkinson, Sanes: "Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy." dans: Cell, Vol. 90, Issue 4, pp. 729-38, (1997) (PubMed).

    Guo, Nichol, Merlie: "Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters." dans: FEBS letters, Vol. 398, Issue 2-3, pp. 259-64, (1997) (PubMed).

    Tinsley, Blake, Roche, Fairbrother, Riss, Byth, Knight, Kendrick-Jones, Suthers, Love: "Primary structure of dystrophin-related protein." dans: Nature, Vol. 360, Issue 6404, pp. 591-3, (1993) (PubMed).

  • Antigène
    Utrophin (UTRN)
    Autre désignation
    Utrophin (UTRN Produits)
    Synonymes
    anticorps drp, anticorps dmdl, anticorps drp1, anticorps DKFZp469A0710, anticorps DMDL, anticorps DRP, anticorps DRP1, anticorps AA589569, anticorps Dmdl, anticorps utrophin L homeolog, anticorps utrophin, anticorps utrn.L, anticorps UTRN, anticorps LOAG_03796, anticorps utrn, anticorps LOC100551145, anticorps Utrn
    Sujet
    Utrophin is an autosomal homolog of dystrophin located on chromosome 6q24. Both encode large cytoskeletal proteins that are members of the spectrin superfamily. Spectrin family proteins are located at the cytoplasmic face and link the intracellular cytoskeleton to the extracellular matrix. Utrophin is nearly identical to dystrophin, specifically in the N-terminal actin binding domain and the C-terminus. Dystrophin is expressed primarily in the brain and muscle, while Utrophin is ubiquitously expressed. In skeletal muscle, Utrophin expression varies depending on the the state of differentiation and innervation of muscle fibers. During development, it localizes in the sarcolemma. Following formation of synaptic contacts, Utrophin is found within the postsynaptic membrane domain of the neuromuscular junction. However, its expression is not limited to postsynaptic compartments. Although dystrophin is absent in patients with Duchenne muscular dystrophy (DMD) and mdx (dystrophin deficient) mice, Utrophin is upregulated. The regulation mechanisms underlying Utrophin expression in muscle have yet to be determined.
    Poids moléculaire
    400 kDa
    Pathways
    Skeletal Muscle Fiber Development
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