GTF2I anticorps (AA 17-123)

N° du produit ABIN968264

Détail du produit anti-GTF2I anticorps

Antigène: GTF2I (General Transcription Factor III (GTF2I))

Épitope: AA 17-123

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GTF2I est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Chien, Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human BAP-135 aa. 17-123

Clone: 42-TFII

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-GTF2I (ABIN968264)

Yang, Desiderio: "BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 2, pp. 604-9, (1997) (PubMed).

Détails sur GTF2I

Antigène: GTF2I (General Transcription Factor III (GTF2I))

Autre désignation: TFII-I (GTF2I Produits)

Synonymes: anticorps BAP135, anticorps BTKAP1, anticorps DIWS, anticorps GTFII-I, anticorps IB291, anticorps SPIN, anticorps TFII-I, anticorps WBS, anticorps WBSCR6, anticorps Gtf2ird1, anticorps 6030441I21Rik, anticorps BAP-135, anticorps GtfII-I, anticorps Spin, anticorps bap-135, anticorps bap135, anticorps btkap1, anticorps diws, anticorps gtfii-i, anticorps ib291, anticorps spin, anticorps tfii-i, anticorps wbs, anticorps wbscr6, anticorps gtf2i, anticorps gtf2i.L, anticorps general transcription factor IIi, anticorps general transcription factor II I, anticorps general transcription factor IIi S homeolog, anticorps GTF2I, anticorps Gtf2i, anticorps gtf2i, anticorps gtf2i.S

Sujet: General transcription factor II-I (GTF2I/TFII-I/SPIN/BAP-135) is a transcription factor that contains six directly repeated 90-residue regions, which possess helix-loop-helix protein-protein interaction motifs. TFII-I can regulate transcription in T-cells through interaction with the initiator elments (Inrs) within the AdML and Vbeta promoters, and associates with HIV-1, TdT, and ribonucleotide reductase R1 Inrs. In addition, TFII-I associates with the E box motif, the CACGTG sequence, and with serum response element sequences. The helix-loop-helix repeats facilitate TFII-I interaction with other transcription factors, such as USF, Myc, Phox 1, MADS box protein serum response factor, and STATs. TFII-I was also identified as Bruton's tyrosine kinase (btk)-associated protein (BAP-135). TFII-I/BAP-135 is tyrosine phosphorylated by btk and after EGF stimulation, and this phosphorylation enhances TFII-I transcriptional activity. The wide expression of TFII-I and the interaction of TFII-I with various Inrs and transcription factors implicates TFII-I in various signaling pathways that regulate gene transcription.
Synonyms: BAP-135

Poids moléculaire: 135/140 kDa