STIM1 anticorps (AA 25-139)

N° du produit ABIN968271

Détail du produit anti-STIM1 anticorps

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Épitope: AA 25-139

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STIM1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus), Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human GOK aa. 25-139

Clone: 44-GOK

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968548, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-STIM1 (ABIN968271)

Hu, Lee, Connors, Johnson, Burn, Su, Landes, Feinberg: "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes." dans: Genomics, Vol. 46, Issue 1, pp. 9-17, (1998) (PubMed).

Overall, Parker, Scarcella, Smith, Dziadek: "Murine Stim1 maps to distal chromosome 7 and is not imprinted." dans: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 9, Issue 8, pp. 657-9, (1998) (PubMed).

Yamauchi, Takeuchi, Overall, Dziadek, Munro, Schreiber: "Structural characteristics of bullfrog (Rana catesbeiana) transthyretin and its cDNA--comparison of its pattern of expression during metamorphosis with that of lipocalin." dans: European journal of biochemistry / FEBS, Vol. 256, Issue 2, pp. 287-96, (1998) (PubMed).

Parker, Begley, Smith, Fox: "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5." dans: Genomics, Vol. 37, Issue 2, pp. 253-6, (1997) (PubMed).

Sabbioni, Barbanti-Brodano, Croce, Negrini: "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development." dans: Cancer research, Vol. 57, Issue 20, pp. 4493-7, (1997) (PubMed).

Détails sur STIM1

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Autre désignation: GOK (STIM1 Produits)

Synonymes: anticorps stim1, anticorps MGC76045, anticorps STIM1, anticorps si:dkey-24p1.5, anticorps MGC154748, anticorps si:ch211-112l17.2, anticorps Stim1, anticorps D11S4896E, anticorps GOK, anticorps TAM, anticorps SIM, anticorps stromal interaction molecule 1, anticorps stromal interaction molecule 1a, anticorps stromal interaction molecule 1 L homeolog, anticorps stromal interaction molecule 1b, anticorps STIM1, anticorps stim1, anticorps stim1a, anticorps stim1.L, anticorps stim1b, anticorps Stim1

Sujet: The human chromosomal region 11p15 has undergone intense analysis because of its association with various malignancies. In particular, the band 11p15.5 contains genes associated with Wilms tumor, Beckwith-Weidemann syndrome, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. One such gene, GOK (Stim 1), was identified near the 5' end of the ribonucleotide reductase subunit 1 gene. Examination of the GOK primary amino acid sequence indicates that it is a typical transmembrane protein with an extracellular N-terminal domain and a cytosolic C-terminal domain. The protein is highly hydrophobic with only a short region of hydrophobicity that likely represents the transmembrane region. The C-terminal portion of GOK shares some small regions of homology with myosin (20% identity). This region of GOK consists of alpha-helices and is thought to adopt a coiled-coil conformation. Although GOK expression has no effect on the growth of certain breast cancer cell lines, it induces death in rhabdomyosarcoma cells. Thus, it is thought to be a recessive tumor suppressor in muscle cells, possibly by functioning as a receptor connected to an apoptotic signaling pathway.
Synonyms: Stim1

Poids moléculaire: 84 kDa

Pathways: TCR Signaling, BCR Signaling