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Dynamitin anticorps (AA 55-196)

DCTN2 Reactivité: Humain, Souris, Rat, Blow Fly WB, IF Hôte: Souris Monoclonal 25-Dynactin p50 unconjugated
N° du produit ABIN968308
  • Antigène Voir toutes Dynamitin (DCTN2) Anticorps
    Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
    Épitope
    • 15
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 55-196
    Reactivité
    • 42
    • 35
    • 17
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Blow Fly
    Hôte
    • 50
    • 5
    • 3
    Souris
    Clonalité
    • 55
    • 3
    Monoclonal
    Conjugué
    • 33
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Dynamitin est non-conjugé
    Application
    • 46
    • 17
    • 13
    • 13
    • 9
    • 9
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Souris, Insectes
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Dynactin p50 aa. 55-196
    Clone
    25-Dynactin p50
    Isotype
    IgG1
    Top Product
    Discover our top product DCTN2 Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Kuo, Liu, Wei, Lin-Lee, Tatebe, Mills, Unate: "Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling." dans: Oncogene, Vol. 21, Issue 13, pp. 1945-54, (2002) (PubMed).

    Holleran, Ligon, Tokito, Stankewich, Morrow, Holzbaur: "beta III spectrin binds to the Arp1 subunit of dynactin." dans: The Journal of biological chemistry, Vol. 276, Issue 39, pp. 36598-605, (2001) (PubMed).

    Starr, Williams, Hays, Goldberg: "ZW10 helps recruit dynactin and dynein to the kinetochore." dans: The Journal of cell biology, Vol. 142, Issue 3, pp. 763-74, (1998) (PubMed).

    Burkhardt, Echeverri, Nilsson, Vallee: "Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution." dans: The Journal of cell biology, Vol. 139, Issue 2, pp. 469-84, (1997) (PubMed).

    Echeverri, Paschal, Vaughan, Vallee: "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis." dans: The Journal of cell biology, Vol. 132, Issue 4, pp. 617-33, (1996) (PubMed).

  • Antigène
    Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
    Autre désignation
    Dynactin p50 (DCTN2 Produits)
    Synonymes
    anticorps DCTN2, anticorps dctn2, anticorps dctn50, anticorps dynamitin, anticorps rbp50, anticorps CG8269, anticorps DMN, anticorps Dmel\\CG8269, anticorps P50, anticorps dDyn, anticorps dmn, anticorps dyna, anticorps l(2)k16109, anticorps l(2)k16218, anticorps p50, anticorps p50/Dmn, anticorps p50/dynamitin, anticorps 2310042E05Rik, anticorps C130077D06Rik, anticorps C87049, anticorps DCTN-50, anticorps GMP23-48K, anticorps RBP50, anticorps DCTN50, anticorps DYNAMITIN, anticorps zgc:63867, anticorps dynactin subunit 2, anticorps dynactin subunit 2 S homeolog, anticorps Dynactin 2, p50 subunit, anticorps dynactin 2, anticorps dynactin 2 (p50), anticorps dynactin subunit 2 L homeolog, anticorps DCTN2, anticorps dctn2.S, anticorps DCTN2-p50, anticorps dctn2, anticorps Dctn2, anticorps dctn2.L
    Sujet
    Dyneins are ubiquitous, multimeric proteins that are responsible for minus end-directed microtubule-based organelle transport. They are divided into two classes, cytosolic and axonemal. The activity of cytosolic dynein is regulated by the multiprotein dynactin complex with which it co-purifies. Dynactin is composed of at least nine polypeptides with p50 being the second most abundant subunit. The complex consists of an F-actin-like core filament of actin-related protein Arp1, a heterodimer that acts as a cap at one end, and a 62kDa subunit at the other end. p150[glued] is the largest subunit of the complex. The precise function of dynactin remains to be determined, but it may be recruited to prometaphase kinetochores to assist in alignment and spindle organization during mitosis. Additionally, dynactin localizes at the tail of cytosolic dynein and activates dynein-mediated vesicle movement. Therefore, dynactin may function to anchor or target dynein to the kinetochore during mitosis.
    Poids moléculaire
    50 kDa
    Pathways
    M Phase, Ribonucleoprotein Complex Subunit Organization
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