PP5 anticorps (AA 36-238)
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- Antigène Voir toutes PP5 (PPP5C) Anticorps
- PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
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Épitope
- AA 36-238
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Reactivité
- Humain, Rat, Souris, Chien
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PP5 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Réactivité croisée
- Souris, Humain, Chien
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Rat PP5 aa. 36-238
- Clone
- 3-PP5
- Isotype
- IgG1
- Top Product
- Discover our top product PPP5C Anticorps primaire
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- Commentaires
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Related Products: ABIN968545, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
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The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions." dans: The EMBO journal, Vol. 17, Issue 5, pp. 1192-9, (1998) (PubMed).
: "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex." dans: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32011-8, (1998) (PubMed).
: "Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest." dans: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12250-8, (1998) (PubMed).
: "Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain." dans: The Journal of biological chemistry, Vol. 269, Issue 36, pp. 22586-92, (1994) (PubMed).
: "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus." dans: The EMBO journal, Vol. 13, Issue 18, pp. 4278-90, (1994) (PubMed).
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The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions." dans: The EMBO journal, Vol. 17, Issue 5, pp. 1192-9, (1998) (PubMed).
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- Antigène
- PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
- Autre désignation
- PP5 (PPP5C Produits)
- Synonymes
- anticorps PP5, anticorps PPP5, anticorps PPT, anticorps AU020526, anticorps pp5, anticorps MGC89961, anticorps fc83f08, anticorps im:7146608, anticorps wu:fc83f08, anticorps zgc:110801, anticorps PPP5C, anticorps protein phosphatase 5 catalytic subunit, anticorps protein phosphatase 5, catalytic subunit, anticorps protein phosphatase 5, catalytic subunit S homeolog, anticorps serine/threonine-protein phosphatase 5, anticorps PPP5C, anticorps Ppp5c, anticorps ppp5c.S, anticorps ppp5c, anticorps LOC592155, anticorps LOC100513542, anticorps LOC100564151, anticorps LOC100186268, anticorps LOC100208775
- Sujet
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Phosphorylation and dephosphorylation on serine and threonine residues is critical for signal transduction and the regulation of numerous cellular functions. Phosphorylation levels are modulated by protein kinases and phosphatases. The Ser/Thr phosphatase PP5 (also known as PPT) is a model protein of the fourth subfamily of the PPP-family of phosphatases which includes PP1, PP2A, and PP2B. PP5 is primarily located in the nucleus, demonstrates widespread tissue distribution, and is highly conserved among species. It consists of a C-terminal catalytic domain and an N-terminal TPR (tetratricopeptide repeat) domain which is involved in protein-protein interactions. The TPRs of PP5 mediate protein phosphatase activity. TPRs mediate the interaction of PP5 with various proteins including the hsp90-glucocorticoid receptor complex and the kinase domain of ANP-guanylate cyclase receptor. PP5 is thought to be important in cell growth. For example, it functions upstream of p53 to regulate p21/WAF1/Cip1-mediated G1 growth arrest. Thus, PP5 is a nuclear protein phosphatase that is involved in signaling pathways of cell growth and arrest. This antibody is routinely tested by western blot analysis.
Synonyms: PPT - Poids moléculaire
- 58 kDa
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