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SRPK1 anticorps (AA 312-434)

SRPK1 Reactivité: Humain, Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 12-SRPK1 unconjugated
N° du produit ABIN968353
  • Antigène Voir toutes SRPK1 Anticorps
    SRPK1 (SRSF Protein Kinase 1 (SRPK1))
    Épitope
    • 15
    • 9
    • 9
    • 7
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 312-434
    Reactivité
    • 60
    • 20
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 55
    • 5
    Souris
    Clonalité
    • 56
    • 4
    Monoclonal
    Conjugué
    • 29
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SRPK1 est non-conjugé
    Application
    • 36
    • 25
    • 13
    • 13
    • 12
    • 10
    • 9
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Rat (Rattus), Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human SRPK1 aa.312-434
    Clone
    12-SRPK1
    Isotype
    IgG1
    Top Product
    Discover our top product SRPK1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968535, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." dans: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).

    Colwill, Feng, Yeakley, Gish, Cáceres, Pawson, Fu: "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors." dans: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24569-75, (1996) (PubMed).

  • Antigène
    SRPK1 (SRSF Protein Kinase 1 (SRPK1))
    Autre désignation
    SRPK1 (SRPK1 Produits)
    Synonymes
    anticorps SFRSK1, anticorps AU017960, anticorps BEST:CK01209, anticorps CG11489, anticorps CG9085, anticorps CK01209, anticorps Dmel\\CG11489, anticorps SRPK, anticorps SRPK1, anticorps Srpk79D, anticorps atc, anticorps srpk1, anticorps zgc:63789, anticorps wu:fc06h03, anticorps zgc:158800, anticorps sfrsk1, anticorps SRSF protein kinase 1, anticorps serine/arginine-rich protein specific kinase 1, anticorps Serine-arginine protein kinase at 79D, anticorps SRSF protein kinase 1a, anticorps SRSF protein kinase 1b, anticorps SRSF protein kinase 1 S homeolog, anticorps SRPK1, anticorps Srpk1, anticorps Srpk79D, anticorps srpk1a, anticorps srpk1b, anticorps srpk1.S
    Sujet
    Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The super family of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate SR domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPL1 is specific for SR domain-containing splicing factors because it recognizes only Arg and phosphorylates only Ser. SRPK1 is expressed predominately in the pancreas, domain-containing splicing factors because it recognizes only Arg and phosphorylates only Ser. SRPK1 is expressed predominately in the pancreas, whereas SRPK2 is highly expressed in brain. SRPKs affect splice-site selection and are thought to affect alternative splicing.
    Poids moléculaire
    92 kDa
    Pathways
    Toll-Like Receptors Cascades
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