ARNT anticorps (AA 461-574)

N° du produit ABIN968356

Détail du produit anti-ARNT anticorps

Antigène: ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))

Épitope: AA 461-574

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ARNT est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: Purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human HIF-1beta/ARNT1

Clone: OPG-01

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 µg/ml

Buffer: Aqueous buffered solution containing BSA, glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ARNT (ABIN968356)

Fallone, Britton, Nieto, Salles, Muller: "ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression." dans: Oncogene, Vol. 32, Issue 37, pp. 4387-96, (2013) (PubMed).

Ambrosini, Nath, Sierra-Honigmann, Flores-Riveros: "Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1." dans: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34601-9, (2002) (PubMed).

Jiang, Jiang, Zheng, Lu, Hunter, Vogt: "Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1." dans: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 12, Issue 7, pp. 363-9, (2001) (PubMed).

Suzuki, Tomida, Tsuruo: "Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia." dans: Oncogene, Vol. 20, Issue 41, pp. 5779-88, (2001) (PubMed).

Maltepe, Schmidt, Baunoch, Bradfield, Simon: "Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT." dans: Nature, Vol. 386, Issue 6623, pp. 403-7, (1997) (PubMed).

Drutel, Kathmann, Heron, Schwartz, Arrang: "Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)." dans: Biochemical and biophysical research communications, Vol. 225, Issue 2, pp. 333-9, (1996) (PubMed).

Détails sur ARNT

Antigène: ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))

Autre désignation: HIF-1beta (ARNT Produits)

Synonymes: anticorps HIF-1-beta, anticorps HIF-1beta, anticorps HIF1-beta, anticorps HIF1B, anticorps HIF1BETA, anticorps TANGO, anticorps bHLHe2, anticorps D3Ertd557e, anticorps Drnt, anticorps ESTM42, anticorps Hif1b, anticorps W08714, anticorps mKIAA4051, anticorps Arnt1, anticorps ARNT, anticorps zgc:136664, anticorps arnt1, anticorps hif1b, anticorps tango, anticorps xArnt, anticorps hif1beta, anticorps hif-1beta, anticorps arnt.2, anticorps MGC68805, anticorps aryl hydrocarbon receptor nuclear translocator, anticorps aryl hydrocarbon receptor nuclear translocator S homeolog, anticorps ARNT, anticorps Arnt, anticorps arnt, anticorps arnt.S

Sujet: The Ah-receptor (AHR) is a ligand activated transcription factor that mediates the biological effects of agonists. AHR dimerizes with a structurally related protein known as ARNT (arylhydrocarbon-receptor nuclear transducer). This heterodimer binds enhancer elements and induces the expression of target genes, specifically those involved in the metabolism of xenobiotics. ARNT1 and ARNT2 are members of the basic-helix-loop-helix-PAS family of heterodimeric transcription factors, which also includes AHR, hypoxia-inducible factor-1alpha (HIF-1alpha), and the Drosophila single-minded protein (Sim). While ARNT2 expression is limited to brain and kidney, ARNT1 exhibits ubiquitous expression. A targeted disruption of the Arnt locus in the mouse yields embryonic stem cells that fail to activate genes that normally respond to low oxygen tension. Arnt -/- embryos do not survive and show defective angiogenesis of the yolk sac and branchial arches, stunted development, and wasting. Thus, in addition to its regulation of xenobiotic metabolism genes, ARNT is thought to induce developmental gene expression resulting in vascularization of the developing embryo.

Poids moléculaire: 95 kDa

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg