CD38 anticorps (AA 171-292)

N° du produit ABIN968373

Détail du produit anti-CD38 anticorps

Antigène: CD38

Épitope: AA 171-292

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD38 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human CD38 aa. 171-292

Clone: 22-CD38

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968584

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-CD38 (ABIN968373)

Deaglio, Morra, Mallone, Ausiello, Prager, Garbarino, Dianzani, Stockinger, Malavasi: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, (1998) (PubMed).

Konopleva, Estrov, Zhao, Andreeff, Mehta: "Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4702-8, (1998) (PubMed).

Détails sur CD38

Antigène: CD38

Abstract: CD38 Produits

Synonymes: anticorps T10, anticorps Cd38-rs1, anticorps cd38, anticorps ADPRC 1, anticorps cADPr hydrolase 1, anticorps CD38 molecule, anticorps CD38 antigen, anticorps CD38 molecule L homeolog, anticorps ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, anticorps CD38, anticorps Cd38, anticorps cd38.L

Sujet: Lymphocyte trafficking is essential for efficient immune responses in that it allows antigen sensitive lymphocytes to encounter antigen and be recruited to sites of infection. Trafficking involves the passage of lymphocytes across the HEV, a process that is mediated by selectins. CD38 is a single-chain type II transmembrane glycoprotein that is expressed by a variety of immature and activated lymphocytes. It mediates a selectin-like binding to endothelial cells, thus functioning as an adhesion molecule. Human and mouse forms of the protein are highly similar and homologous to the Aplysia californica ADP-ribosyl-cyclase. CD38 catalyzes the synthesis of cyclic ADP-ribose (cADPR), a putative endogenous regulator of calcium release. This is thought to be key to CD38-mediated signal transduction. A possible ligand for CD38 is the Ig superfamily protein CD31. In addition, activation of CD38 with a monoclonal antibody induces leukemic cell proliferation. Thus, CD38 is a cell surface protein that is important for lymphocyte migration and may be involved in the propagation of leukemic cells in AML (acute myelogenous leukemia).

Poids moléculaire: 46 kDa