SRPK2 anticorps (AA 363-485)

N° du produit ABIN968376

Détail du produit anti-SRPK2 anticorps

Antigène: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Épitope: AA 363-485

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SRPK2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Souris, Rat (Rattus), Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human SRPK2 aa. 363-485

Clone: 23-SRPK2

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968533, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-SRPK2 (ABIN968376)

Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." dans: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).

Détails sur SRPK2

Antigène: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Autre désignation: SRPK2 (SRPK2 Produits)

Synonymes: anticorps SFRSK2, anticorps AW226533, anticorps AW492537, anticorps AW547358, anticorps Wbp6, anticorps mSRPK2, anticorps sfrsk2, anticorps srpk2, anticorps srpk2-b, anticorps srpk2b, anticorps SRSF protein kinase 2, anticorps serine/arginine-rich protein specific kinase 2, anticorps SRSF protein kinase 2 L homeolog, anticorps SRPK2, anticorps Srpk2, anticorps srpk2, anticorps srpk2.L

Sujet: Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The superfamily of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and their function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate RS domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPK1 is predominate in the pancreas, whereas SRPK2 is highly expressed in brain. SRPK2 contains an N-terminal proline-rich sequence that mediates its in vitro interaction with a WW domain containing protein. SRPKs affect splice-site selection and are thought to affect alternative splicing. This antibody is routinely tested by western blot analysis.
Synonyms: SR Protein specific Kinase-2

Poids moléculaire: 115 kDa

Pathways: Ribonucleoprotein Complex Subunit Organization