G3BP1 anticorps (AA 210-323)

N° du produit ABIN968381

Détail du produit anti-G3BP1 anticorps

Antigène: G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))

Épitope: AA 210-323

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp G3BP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human G3BP aa. 210-323

Clone: 23-G3BP

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968552, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-G3BP1 (ABIN968381)

Gallouzi, Parker, Chebli, Maurier, Labourier, Barlat, Capony, Tocque, Tazi: "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability." dans: Molecular and cellular biology, Vol. 18, Issue 7, pp. 3956-65, (1998) (PubMed).

Parker, Maurier, Delumeau, Duchesne, Faucher, Debussche, Dugue, Schweighoffer, Tocque: "A Ras-GTPase-activating protein SH3-domain-binding protein." dans: Molecular and cellular biology, Vol. 16, Issue 6, pp. 2561-9, (1996) (PubMed).

Détails sur G3BP1

Antigène: G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))

Autre désignation: G3BP (G3BP1 Produits)

Synonymes: anticorps G3BP, anticorps HDH-VIII, anticorps fj17h05, anticorps zgc:56034, anticorps wu:fj17h05, anticorps g3bp, anticorps MGC53271, anticorps G3BP1, anticorps G3bp, anticorps RGD1310666, anticorps AI849976, anticorps B430204O07, anticorps C87777, anticorps mKIAA4115, anticorps G3BP stress granule assembly factor 1, anticorps GTPase activating protein (SH3 domain) binding protein 1, anticorps GTPase activating protein (SH3 domain) binding protein 1 L homeolog, anticorps Ras-GTPase-activating protein SH3-domain-binding protein, anticorps G3BP1, anticorps g3bp1, anticorps g3bp1.L, anticorps LOC100304885, anticorps G3bp1

Sujet: The Ras proteins are low molecular weight GTPases that play a critical role in the control of proliferation, differentiation, and cytoskeletal organization. RasGAP acts as a negative regulator of Ras, as well as a downstream target of Ras. It participates in the signal transduction cascade through interactions with other signaling proteins. Via its C-terminal domain, RasGAP interacts with Ras, but the N-terminus interacts with other signaling molecules such as p62 and p190. This function of RasGAP is mediated by the presence of SH2, SH3, and PH domains in the N-terminal region. However, some signaling proteins cannot bind to these domains. In an attempt to identify RasGAP-interacting molecules, a GAP SH3-Binding Protein (G3BP) was identified. This protein exhibits sequence homology to the hnRNP superfamily. It contains RNP1 and RNP2 motifs and is found primarily in the cytosol. G3BP interacts with GAP in proliferating cells and is dependent on the activation state of Ras. In addition, G3BP contains an intrinsic endonuclease activity that cleaves 3'-untranslated region (3'-UTR) mRNA. These data indicate that G3BP may link the Ras pathway to mRNA degradation.

Poids moléculaire: 55-70 kDa

Pathways: SARS-CoV-2 Protein Interactome