STXBP5 anticorps (AA 910-1105)

N° du produit ABIN968460

Détail du produit anti-STXBP5 anticorps

Antigène: STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))

Épitope: AA 910-1105

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STXBP5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)

Réactivité croisée: Souris, Humain

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat Tomosyn aa. 910-1105

Clone: 15-Tomosyn

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-STXBP5 (ABIN968460)

Yokoyama, Shirataki, Sakisaka, Takai: "Three splicing variants of tomosyn and identification of their syntaxin-binding region." dans: Biochemical and biophysical research communications, Vol. 256, Issue 1, pp. 218-22, (1999) (PubMed).

Fujita, Shirataki, Sakisaka, Asakura, Ohya, Kotani, Yokoyama, Nishioka, Matsuura, Mizoguchi, Scheller, Takai: "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process." dans: Neuron, Vol. 20, Issue 5, pp. 905-15, (1998) (PubMed).

Détails sur STXBP5

Antigène: STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))

Autre désignation: Tomosyn (STXBP5 Produits)

Synonymes: anticorps LGL3, anticorps LLGL3, anticorps Nbla04300, anticorps 0710001E20Rik, anticorps 4930565N16Rik, anticorps AW742610, anticorps mKIAA1006, anticorps syntaxin binding protein 5, anticorps syntaxin binding protein 5 (tomosyn), anticorps STXBP5, anticorps Stxbp5

Sujet: Neuronal signal transmission and neurotransmitter release from the presynaptic nerve terminal is mediated by the synaptic vesicle cycle. Syntaxin plays a central role during vesicle docking and fusion through interactions with many vesicle components. During docking, vSNAREs (VAMP/synaptobrevin, synaptotagmin) on the synaptic vesicle and tSNAREs (SNAP-25, syntaxin) on the plasma membrane interact to form a 7S complex, which is essential to docking and fusion. Syntaxin associates with munc18/n-sec1 prior to and/or during the formation of the 7S complex. This interaction may inhibit syntaxin binding proteins (VAMP, SNAP-25) that facilitate vesicle docking or fusion. Tomosyn, a syntaxin binding protein, displaces munc18 from syntaxin-1 and forms a novel 10S complex with syntaxin-1, SNAP-25, and synaptogamin. There are two splice variants of tomosyn designated b-tomosyn and s-tomosyn, while the original is referred to as m-tomosyn. Although b-tomosyn is ubiquitously expressed, s-tomosyn and m-tomosyn are expressed primarily in brain. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 130 kDa