Sorting Nexin 2 anticorps (AA 15-137)

N° du produit ABIN968465

Détail du produit anti-Sorting Nexin 2 anticorps

Antigène: Sorting Nexin 2 (SNX2)

Épitope: AA 15-137

Reactivité: Humain, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Sorting Nexin 2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human SNX2 aa. 15-137

Clone: 13-SNX2

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Sorting Nexin 2 (ABIN968465)

Haft, de la Luz Sierra, Barr, Haft, Taylor: "Identification of a family of sorting nexin molecules and characterization of their association with receptors." dans: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7278-87, (1998) (PubMed).

Kurten, Cadena, Gill: "Enhanced degradation of EGF receptors by a sorting nexin, SNX1." dans: Science (New York, N.Y.), Vol. 272, Issue 5264, pp. 1008-10, (1996) (PubMed).

Détails sur Sorting Nexin 2

Antigène: Sorting Nexin 2 (SNX2)

Autre désignation: SNX2 (SNX2 Produits)

Synonymes: anticorps snx2, anticorps MGC64590, anticorps SNX2, anticorps LOC100219194, anticorps TRG-9, anticorps 0610030A03Rik, anticorps zgc:123293, anticorps sorting nexin 2 S homeolog, anticorps sorting nexin 2, anticorps snx2.S, anticorps SNX2, anticorps BACOIKO006_25, anticorps snx2, anticorps Snx2

Sujet: Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX) domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1 directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1, SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX2 and other sorting nexins are thought to play important roles in the specificity of protein trafficking to and from the plasma membrane. This antibody is routinely tested by western blot analysis.
Synonyms: Sorting Nexin-2

Poids moléculaire: 72 kDa