NMT2 anticorps (AA 10-119)

N° du produit ABIN968466

Détail du produit anti-NMT2 anticorps

Antigène: NMT2 (N-Myristoyltransferase 2 (NMT2))

Épitope: AA 10-119

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NMT2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human NMT-2 aa. 10-119

Clone: 30-NMT

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-NMT2 (ABIN968466)

Giang, Cravatt: "A second mammalian N-myristoyltransferase." dans: The Journal of biological chemistry, Vol. 273, Issue 12, pp. 6595-8, (1998) (PubMed).

Détails sur NMT2

Antigène: NMT2 (N-Myristoyltransferase 2 (NMT2))

Autre désignation: NMT-2 (NMT2 Produits)

Synonymes: anticorps NMT2, anticorps A930001K02Rik, anticorps AI605445, anticorps AU044698, anticorps hNMT-2, anticorps NMT 2, anticorps fb40e03, anticorps wu:fb40e03, anticorps N-myristoyltransferase 2, anticorps NMT2, anticorps Bm1_22900, anticorps LOAG_05681, anticorps nmt2, anticorps Nmt2

Sujet: Myristoylation is an essential cotranslational modification for many mammalian, viral, and fungal signaling proteins. N-terminal myristoylation is a lipid modification that is catalyzed by N-myristoyltransferase (NMT). NMT transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. This modification is important for localization and/or function of many of these proteins. Two human NMTs (NMT-1, NMT-2) have been identified. These proteins share 95% amino acid identity with their mouse homologs. NMT-1 is processed to form four protein isoforms with molecular weights ranging from 49-68 kDa. It is not known if these four isoforms are derived from single or multiple gene(s) and their exact functional roles are yet to be determined. In contrast to NMT-1, NMT-2 is a single 65 kDa protein. It contains 77% sequence identity with NMT-1, indicating that these proteins comprise two distinct families with overlapping, but distinct, substrate preferences. Additionally, NMT enzymatic activity is increased in colorectal tumors. Thus, NMTs are transferases whose function is essential for biological function of a variety of signaling proteins.

Poids moléculaire: 65 kDa

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling