KIF3A anticorps (AA 563-671)

N° du produit ABIN968567

Détail du produit anti-KIF3A anticorps

Antigène: KIF3A (Kinesin Family Member 3A (KIF3A))

Épitope: AA 563-671

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIF3A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus), Souris

Attributs du produit: 1. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human KIF3A aa. 563-671

Clone: 28-KIF3A

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-KIF3A (ABIN968567)

Marszalek, Ruiz-Lozano, Roberts, Chien, Goldstein: "Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 9, pp. 5043-8, (1999) (PubMed).

Muresan, Lyass, Schnapp: "The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 3, pp. 1027-37, (1999) (PubMed).

Hirokawa: "Kinesin and dynein superfamily proteins and the mechanism of organelle transport." dans: Science (New York, N.Y.), Vol. 279, Issue 5350, pp. 519-26, (1998) (PubMed).

Détails sur KIF3A

Antigène: KIF3A (Kinesin Family Member 3A (KIF3A))

Autre désignation: KIF3A (KIF3A Produits)

Synonymes: anticorps FLA10, anticorps KLP-20, anticorps 111-11-71, anticorps 111-11-86, anticorps AW124694, anticorps Kif3, anticorps Kifl, anticorps Kns3, anticorps kinesin family member 3A, anticorps kinesin family member 3a, anticorps KIF3A, anticorps Kif3a

Sujet: The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF3A/3B, KRP85/95, and Klp68d/64. These proteins form heterodimeric two-headed motors that interact with kinesin associated protein (KAP). The KIF3A/3B/KAP3 heterotrimeric motor has plus-end directed microtubule sliding activity. This heterotrimeric motor is expressed ubiquitously and is used for anterograde transport of membranous organelles. KIF3A- and KIF3B-deficient mice have defects in the formation of the cilia located in the embryonic node. In addition, KIF3A localizes to the basal body of the connecting cilium axoneme and to vesicles at the pre-synaptic ribbon in photoreceptor cells. Thus, KIF3 motors are involved in microtubule-based formation and movement of cilia and the transport of synaptic vesicles. This antibody is routinely tested by the Western blot analysis.

Poids moléculaire: 80/85 kDa

Pathways: Signalisation Hedgehog