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ARHGEF7 anticorps (AA 351-453)

ARHGEF7 Reactivité: Rat, Souris, Poulet, Chien WB, IF Hôte: Souris Monoclonal 23-bPIX unconjugated
N° du produit ABIN968623
  • Antigène Voir toutes ARHGEF7 Anticorps
    ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))
    Épitope
    • 15
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-453
    Reactivité
    Rat, Souris, Poulet, Chien
    Hôte
    • 46
    • 2
    Souris
    Clonalité
    • 47
    • 1
    Monoclonal
    Conjugué
    • 19
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ARHGEF7 est non-conjugé
    Application
    • 23
    • 22
    • 13
    • 13
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Poulet, Chien, Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Rat betaPIX aa. 351-453
    Clone
    23-bPIX
    Isotype
    IgG1
    Top Product
    Discover our top product ARHGEF7 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Turner, Brown, Perrotta, Riedy, Nikolopoulos, McDonald, Bagrodia, Thomas, Leventhal: "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling." dans: The Journal of cell biology, Vol. 145, Issue 4, pp. 851-63, (1999) (PubMed).

    Bagrodia, Taylor, Jordon, Van Aelst, Cerione: "A novel regulator of p21-activated kinases." dans: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23633-6, (1998) (PubMed).

    Manser, Loo, Koh, Zhao, Chen, Tan, Tan, Leung, Lim: "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors." dans: Molecular cell, Vol. 1, Issue 2, pp. 183-92, (1998) (PubMed).

    Oh, Yoo, Jo, Song, Kim, Park: "Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion." dans: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 794-8, (1997) (PubMed).

  • Antigène
    ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))
    Autre désignation
    beta PIX (ARHGEF7 Produits)
    Synonymes
    anticorps BETA-PIX, anticorps COOL-1, anticorps COOL1, anticorps Nbla10314, anticorps P50, anticorps P50BP, anticorps P85, anticorps P85COOL1, anticorps P85SPR, anticorps PAK3, anticorps PIXB, anticorps cool1, anticorps p50, anticorps p85, anticorps pak3, anticorps pixb, anticorps ARHGEF7, anticorps P85spr, anticorps Pak3bp, anticorps Cool, anticorps PIX, anticorps betaPix, anticorps betaPix-b, anticorps betaPix-c, anticorps cool-1, anticorps mKIAA0142, anticorps p85Cool1, anticorps p85SPR, anticorps arhgef7, anticorps bbh, anticorps bpix, anticorps im:7142367, anticorps wu:fc35h08, anticorps zgc:101775, anticorps Rho guanine nucleotide exchange factor 7, anticorps Rho guanine nucleotide exchange factor 7 S homeolog, anticorps ankyrin repeat domain 10, anticorps Rho guanine nucleotide exchange factor (GEF7), anticorps Rho guanine nucleotide exchange factor (GEF) 7b, anticorps ARHGEF7, anticorps arhgef7.S, anticorps arhgef7, anticorps ANKRD10, anticorps Arhgef7, anticorps arhgef7b
    Sujet
    The activity of PAK family kinases is regulated through interaction with the small GTPases Cdc42 and Rac1. PAKs are activated by the GTP-bound form of Cdc-42 and Rac1, and recruitment of PAKs to focal complexes has been implicated in Cdc42- and Rac1-dependent regulation of focal contact formation. PAK-interacting exchange factor (PIX) was identified in a screen for proteins that bind PAKs. Two forms of PIX have been identified: an 85 kDa protein designated alphaPIX and a 78 kDa protein designated betaPIX. These proteins have 80% identity in their overlapping regions, which include myosin-like, pleckstrin (PH), Dbl (DH), and SH3 domains. In addition, alphaPIX contains a calponin-like domain at the N-terminus. The expression of betaPIX is ubiquitous, while alphaPIX is expressed in heart, muscle, and thymus. PIX can act as a guanine nuleotide exchange factor for Rac1 and co-transfection of betaPIX, Cdc42, and alphaPAK results in increased alphaPAK activity. PIX binding to PAK is required for localization of PAKs to focal complexes and injection of betaPIX leads to rac1-dependent membrane ruffling. Thus, PIX is important for PAK localization and activity during small GTPase-dependent regulation of cell morphology.
    Poids moléculaire
    78 kDa
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
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