SLC1A2 anticorps (AA 562-574)
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- Antigène Voir toutes SLC1A2 Anticorps
- SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))
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Épitope
- AA 562-574
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Reactivité
- Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SLC1A2 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée
- Rat (Rattus)
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human EAAT2 aa. 562-574
- Clone
- 20-EAAT2
- Isotype
- IgG1
- Top Product
- Discover our top product SLC1A2 Anticorps primaire
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- Commentaires
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Related Products: ABIN968545, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
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The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate." dans: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9684-9, (2000) (PubMed).
: "Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 15, pp. 5706-13, (1998) (PubMed).
: "Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1." dans: Science (New York, N.Y.), Vol. 276, Issue 5319, pp. 1699-702, (1997) (PubMed).
: "Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2." dans: Genomics, Vol. 24, Issue 2, pp. 218-24, (1995) (PubMed).
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The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate." dans: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9684-9, (2000) (PubMed).
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- Antigène
- SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))
- Autre désignation
- EAAT2 (SLC1A2 Produits)
- Synonymes
- anticorps CG3159, anticorps Dmel\\CG3159, anticorps EAAT, anticorps dEAAT2, anticorps dEaat2, anticorps Eaat, anticorps GB16377, anticorps EAAT2, anticorps SLC1A2, anticorps Eaat2, anticorps Glt, anticorps Glt-1, anticorps GLT-1, anticorps 1700091C19Rik, anticorps 2900019G14Rik, anticorps AI159670, anticorps GLT1, anticorps MGLT1, anticorps eaat2, anticorps fj34b12, anticorps slc1a2, anticorps wu:fj34b12, anticorps zgc:65897, anticorps Excitatory amino acid transporter 2, anticorps excitatory amino acid transporter 2, anticorps solute carrier family 1 member 2, anticorps solute carrier family 1 (glial high affinity glutamate transporter), member 2, anticorps solute carrier family 1 (glial high affinity glutamate transporter), member 2b, anticorps Eaat2, anticorps Eaat-2, anticorps SLC1A2, anticorps VDBG_06180, anticorps EUBELI_01747, anticorps Trebr_0139, anticorps Slc1a2, anticorps slc1a2b
- Sujet
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Electrogenic-coupled (Na+ and K+) glutamate transporters in nerve terminals and glial cells are essential for maintaining subtoxic levels of extracellular excitatory amino acid neurotransmitters (e.g. glutamate and aspartate). They are also important for modifying synaptic transmission through the cotransport of ions and neurotransmitters. Excitatory amino acid transporter 2 (EAAT2) has 8 alpha-helical transmembrane domains and two reentrant pore-loop-like structures whose conformation is altered during ion neurotransmitter transport. EAAT2 is primarily expressed in astrocytes in adult brain and spinal cord, however it is also found in axons during fetal development. Mice deficient in EAAT2 exhibit lethal epileptic seizures with destruction of hippocampal neurons and an increased susceptibility to cold-induced cortical injury. Such defects in glutamine transporters have also been implicated in stroke, brain trauma, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Thus, glutamine transporters, such as EAAT2, are critical for prevention of neurotoxic brain injury and may regulate glutamatergic synaptic transmission. This antibody is routinely tested by western blot analysis.
Synonyms: Excitatory amino acid transporter 2, Glutamate transporter 1, GLT1 - Poids moléculaire
- 66 kDa
- Pathways
- Dicarboxylic Acid Transport
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