Doublecortin anticorps (AA 211-317)
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- Antigène Voir toutes Doublecortin (DCX) Anticorps
- Doublecortin (DCX)
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Épitope
- AA 211-317
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Reactivité
- Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Doublecortin est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Mouse Doublecortin aa. 211-317
- Clone
- 30-Doublecortin
- Isotype
- IgG1
- Top Product
- Discover our top product DCX Anticorps primaire
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- Commentaires
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Related Products: ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
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Induction of neurogenesis in the neocortex of adult mice." dans: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).
: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." dans: Cell, Vol. 92, Issue 1, pp. 51-61, (1998) (PubMed).
: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." dans: Cell, Vol. 92, Issue 1, pp. 63-72, (1998) (PubMed).
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Induction of neurogenesis in the neocortex of adult mice." dans: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).
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- Antigène
- Doublecortin (DCX)
- Autre désignation
- Doublecortin (DCX Produits)
- Synonymes
- anticorps DCX, anticorps DBCN, anticorps DC, anticorps LISX, anticorps SCLH, anticorps XLIS, anticorps Dbct, anticorps 18C15.5, anticorps doublecortin, anticorps DCX, anticorps Dcx
- Sujet
- The cerebral cortex is composed of multiple layers of neurons of distinct types and functions, which perform in unison to orchestrate cognitive function. The formation of the cortex relies on complex signaling mechanisms, which mediate the migration of newly formed neurons from deep within the brain to the superficial regions. Defects in neuronal migration and disruption of the multi-layered cortex are apparent in conditions such as X-linked lissencephaly (XLIS) and subcortical laminar heterotopia (SCLH) or double cortex (DC) syndrome. Mutations in the doublecortin gene have been linked to these brain disorders. Doublecortin is highly expressed in developing brain, primarily in migrating neurons. It is significantly homologous with the N-terminal region of the product of the KIAA0369 gene, a protein that is also similar to the CaM kinase family in its C-terminal region. Doublecortin has four potential MAP kinase family phosphorylation sites and a putative site for Abl tyrosine phosphorylation. Thus, doublecortin is thought to be an integral component of tyrosine kinase signal transduction pathways that regulate neuronal migration and development of the cerebral cortex.
- Poids moléculaire
- 41 kDa
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