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Thyroid Hormone Receptor Interactor 11 (TRIP11) (AA 159-365) anticorps

TRIP11 Reactivité: Humain WB, IF Hôte: Souris Monoclonal 15-GMAP unconjugated
N° du produit ABIN968639
  • Antigène Voir toutes Thyroid Hormone Receptor Interactor 11 (TRIP11) Anticorps
    Thyroid Hormone Receptor Interactor 11 (TRIP11)
    Épitope
    • 1
    • 1
    • 1
    AA 159-365
    Reactivité
    Humain
    Hôte
    • 10
    • 1
    Souris
    Clonalité
    • 10
    • 1
    Monoclonal
    Conjugué
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Inconjugué
    Application
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human GMAP-210 aa. 159-365
    Clone
    15-GMAP
    Isotype
    IgG1
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Chen, Chen, Chen, Sharp, Lee: "Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4443-8, (1999) (PubMed).

    Infante, Ramos-Morales, Fedriani, Bornens, Rios: "GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein." dans: The Journal of cell biology, Vol. 145, Issue 1, pp. 83-98, (1999) (PubMed).

    Chang, Chen, Chen, Chou, Chen, Ma, Yang-Feng, Leng, Tsai, OMalley, Lee: "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 17, pp. 9040-5, (1997) (PubMed).

  • Antigène
    Thyroid Hormone Receptor Interactor 11 (TRIP11)
    Autre désignation
    GMAP-210 (TRIP11 Produits)
    Synonymes
    anticorps ACG1A, anticorps CEV14, anticorps GMAP-210, anticorps TRIP-11, anticorps TRIP230, anticorps cb423, anticorps sb:cb423, anticorps sb:cb721, anticorps wu:fb71d07, anticorps MGC79667, anticorps 2610511G22Rik, anticorps 3110031G15Rik, anticorps 6030460N08Rik, anticorps AI450776, anticorps thyroid hormone receptor interactor 11, anticorps thyroid hormone receptor interactor 11 L homeolog, anticorps TRIP11, anticorps trip11, anticorps trip11.L, anticorps Trip11
    Sujet
    Trip230 was identified as a protein that interacts with retinoblastoma protein (Rb) and the thyroid hormone receptor (TR). The structure of Trip230 includes five coiled-coil segments separated by non-helical linkers, N-terminal and C-terminal leucine zipper domains, and multiple phosphorylation sites. Trip230 is ubiquitously expressed and localized to the Golgi. During cell cycle progression, a significant portion of Trip230 translocates to the nucleus. In addition, activation of TR with thyroid hormone (T3) leads to phosphorylation of Trip230, as well as Trip230 translocation from the Golgi to the nucleus. Interestingly, Trip230 has also been identified as a Golgi microtubule-associated protein of 210 kDa (GMAP-210). In vitro , GMAP-210 can bind to the minus end of alpha-tubulin and gamma-tubulin via its C-terminal region, while the N-terminal region is involved in Golgi binding. Overexpression of GMAP-210 leads to enlargement of the Golgi apparatus and alterations in the microtubule cytoskeleton. Thus, GMAP-210/Trip230 is thought to function both as a TR coactivator and as a microtubule-binding protein that anchors the Golgi to the microtubule cytoskeleton.
    Synonyms: Trip230
    Poids moléculaire
    210 kDa
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