Density Regulated Protein anticorps (AA 19-201)

N° du produit ABIN968651

Détail du produit anti-Density Regulated Protein anticorps

Antigène: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Épitope: AA 19-201

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Density Regulated Protein est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Souris, Rat (Rattus), Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Drp1 aa. 19-201

Clone: 22-Drp1

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968551, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Density Regulated Protein (ABIN968651)

Deyo, Chiao, Tainsky: "drp, a novel protein expressed at high cell density but not during growth arrest." dans: DNA and cell biology, Vol. 17, Issue 5, pp. 437-47, (1998) (PubMed).

Détails sur Density Regulated Protein

Antigène: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Autre désignation: Density-regulated protein (DENR Produits)

Synonymes: anticorps DRP, anticorps DRP1, anticorps SMAP-3, anticorps DENR, anticorps 1500003K04Rik, anticorps drp, anticorps drp1, anticorps smap-3, anticorps MGC79758, anticorps MGC107862, anticorps im:6891640, anticorps zgc:113309, anticorps zgc:92629, anticorps denr, anticorps Denr, anticorps DDBDRAFT_0205981, anticorps DDBDRAFT_0266779, anticorps DDB_0205981, anticorps DDB_0266779, anticorps density regulated re-initiation and release factor, anticorps density-regulated protein L homeolog, anticorps density-regulated protein, anticorps Density-regulated protein, anticorps density regulated reinitiation and release factor, anticorps DENR, anticorps denr.L, anticorps Denr, anticorps denr, anticorps EHI_065830, anticorps CpipJ_CPIJ009942, anticorps MCYG_07531, anticorps Tsp_00169

Sujet: In culture, cell density can have profound effects on gene expression, enzymatic activity, and cell signaling pathways. Using differential screening of cDNAs from low-passage nontumorigenic teratocarcinoma cells versus high passage tumorigenic cells, a protein was identified that is regulated in cell-density dependent manner. This protein, density-regulated protein 1 (drp1), contains putative sites for N-myristoylation and phosphorylation sites for cAMP and/or cGMP-dependent kinase, casein kinase II, and PKC. The expression of drp1 is enriched in high density cultures of both nontumorigenic and tumorigenic cell lines and is widely detected in adult organs, especially skeletal and cardiac muscle. In addition, increased expression of drp1 is not due to growth arrest as a result of serum starvation or TGF-beta treatment nor is it a result of factors found in the media of high density cultures. Interestingly, drp1 is expressed highest in skeletal and cardiac muscle where unique cell-cell contacts are involved in muscle cell membrane depolarization and contraction. Thus, drp1 expression may be regulated by signaling pathways related to specific types of cell-cell contacts. This antibody is routinely tested by western blot analysis.
Synonyms: Density Regulated Protein-1

Poids moléculaire: 27 kDa