MAPK8IP1 anticorps (AA 180-384)

N° du produit ABIN968696

Détail du produit anti-MAPK8IP1 anticorps

Antigène: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Épitope: AA 180-384

Reactivité: Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPK8IP1 est non-conjugé

Application: Western Blotting (WB), Fluorescence Microscopy (FM)

Réactivité croisée: Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse JIP-1 aa. 180-384

Clone: 50-JIP

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-MAPK8IP1 (ABIN968696)

Meyer, Liu, Margolis: "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons." dans: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 35113-8, (2000) (PubMed).

Bonny, Nicod, Waeber: "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells." dans: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1843-6, (1998) (PubMed).

Dickens, Rogers, Cavanagh, Raitano, Xia, Halpern, Greenberg, Sawyers, Davis: "A cytoplasmic inhibitor of the JNK signal transduction pathway." dans: Science (New York, N.Y.), Vol. 277, Issue 5326, pp. 693-6, (1997) (PubMed).

Détails sur MAPK8IP1

Antigène: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Autre désignation: JIP-1 (MAPK8IP1 Produits)

Synonymes: anticorps IB1, anticorps JIP-1, anticorps Jip1, anticorps Prkm8ip, anticorps Skip, anticorps mjip-2a, anticorps JIP1, anticorps Jip-1, anticorps Mapk8ip, anticorps PRKM8IP, anticorps mitogen-activated protein kinase 8 interacting protein 1, anticorps MAPK8IP1, anticorps Mapk8ip1

Sujet: The JNK group of MAPKs is activated by a variety of inflammatory cytokines and environmental stressors. Activated JNK phosphorylates many cellular proteins, such as components of the AP-1 transcription factor complex (c-Jun and ATF-2). JNK-interacting proteins (JIPs) bind JNK, MKK7, MLKs, p190RhoGEF, and the Ste20-related protein kinase HPK1. In mouse, alternative splicing of JIP produces multiple splice variants, JIP-1, JIP-1b, JIP-2a, JIP-2b, and JIP-3. The structure of full length JIP consists of two N-terminal acidic regions, a JNK binding domain (JBD), two proline rich regions (PR), and both an SH3 and a phosphotyrosine-binding domain in the C-terminal region. JIP-1 localizes to the tips of neurites in differentiated PC12 cells, and may interact with JNK, MKK7, and MLK to facilitate formation of the JNK activating complex. IB1 is the rat homologue of JIP-1b, a JIP-1 variant that includes a 47 amino acid insert in the C-terminal region. IB1 is found in the nucleus and cytoplasm, and may function as a transactivator of the GLUT2 gene. Thus, JIP-1 and its related isoforms may have multiple functions that involve specific protein-protein interactions.
Synonyms: JNK Interacting Protein

Poids moléculaire: 112 kDa