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MTTP anticorps (AA 91-288)

MTTP Reactivité: Souris, Rat WB, IF Hôte: Souris Monoclonal 8-MTP unconjugated
N° du produit ABIN968716
  • Antigène Voir toutes MTTP Anticorps
    MTTP (Microsomal Triglyceride Transfer Protein (MTTP))
    Épitope
    • 11
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 91-288
    Reactivité
    • 40
    • 17
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 40
    • 2
    Souris
    Clonalité
    • 43
    Monoclonal
    Conjugué
    • 22
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTTP est non-conjugé
    Application
    • 30
    • 21
    • 20
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse MTP aa. 91-288
    Clone
    8-MTP
    Isotype
    IgG2a
    Top Product
    Discover our top product MTTP Anticorps primaire
  • Commentaires

    Related Products: ABIN968543, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Chen, Newberry, Norris, Xie, Luo, Kennedy, Davidson: "ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice." dans: Journal of lipid research, Vol. 49, Issue 9, pp. 2013-22, (2008) (PubMed).

    Qin, Anderson, Adeli: "Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 5, pp. G1120-9, (2008) (PubMed).

    Morral, Edenberg, Witting, Altomonte, Chu, Brown: "Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver." dans: Journal of lipid research, Vol. 48, Issue 7, pp. 1499-510, (2007) (PubMed).

    Read, Anderson, Ritchie, Vanloo, Amey, Levitt, Rosseneu, Scott, Shoulders: "A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein." dans: The Journal of biological chemistry, Vol. 275, Issue 39, pp. 30372-7, (2000) (PubMed).

    Wetterau, Gregg, Harrity, Arbeeny, Cap, Connolly, Chu, George, Gordon, Jamil, Jolibois, Kunselman, Lan, Maccagnan, Ricci, Yan, Young, Chen, Fryszman, Logan, Musial, Poss, Robl, Simpkins, Slusarchyk et al.: "An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. ..." dans: Science (New York, N.Y.), Vol. 282, Issue 5389, pp. 751-4, (1998) (PubMed).

    Nakamuta, Chang, Hoogeveen, Li, Chan: "Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression and chromosomal localization." dans: Genomics, Vol. 33, Issue 2, pp. 313-6, (1997) (PubMed).

  • Antigène
    MTTP (Microsomal Triglyceride Transfer Protein (MTTP))
    Autre désignation
    MTP (MTTP Produits)
    Synonymes
    anticorps ABL, anticorps MTP, anticorps 1810043K16Rik, anticorps CG9342, anticorps CT3751, anticorps Dmel\\CG9342, anticorps dMTP, anticorps wu:fd36b01, anticorps zgc:111876, anticorps microsomal triglyceride transfer protein, anticorps Microsomal triacylglycerol transfer protein, anticorps MTTP, anticorps Mttp, anticorps Mtp, anticorps mttp
    Sujet
    The microsomal triglyceride transfer protein (MTP) catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between membranes within the lumen of microsomes in hepatocytes and enterocytes. MTP forms a heterodimer with the 58 kDa protein disulfide isomerase. PDI catalyzes the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configuration within proteins. MTP is mutated in abetalipoproteinemia, which results from defects in apolipoprotein-B (apoB)-containing lipoproteins. A lack of MTP expression prevents secretion of apoB from mammalian cells, leading to intracellular degradation. In the C-terminal region, MTP has structural homology to apoB and the lamprey lipovitellin protein. This region contains a membrane binding helix (Helix A), and a triglyceride binding helix (Helix B). Mutations in Helix B cause abetalipoproteinemia. In addition, inhibitors of MTP activity may be important therapeutics for lowering atherogenic lipoprotein levels. Thus, MTP is a microsomal protein that is required for transport of lipids between membranes in liver and small intestines.
    Synonyms: Microsomal Triglyceride transfer Protein
    Poids moléculaire
    97 kDa
    Pathways
    Transition Metal Ion Homeostasis
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