SRR anticorps (AA 127-248)

N° du produit ABIN968727

Détail du produit anti-SRR anticorps

Antigène: SRR (Serine Racemase (SRR))

Épitope: AA 127-248

Reactivité: Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SRR est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse serine racemase aa. 127-248

Clone: 29-Serine Racemase

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968540, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-SRR (ABIN968727)

Mothet, Parent, Wolosker, Brady, Linden, Ferris, Rogawski, Snyder: "D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4926-31, (2000) (PubMed).

Wolosker, Blackshaw, Snyder: "Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13409-14, (1999) (PubMed).

Détails sur SRR

Antigène: SRR (Serine Racemase (SRR))

Autre désignation: Serine Racemase (SRR Produits)

Synonymes: anticorps DDBDRAFT_0188432, anticorps DDBDRAFT_0230209, anticorps DDB_0188432, anticorps DDB_0230209, anticorps ilv1, anticorps iso1, anticorps ILV1, anticorps ISO1, anticorps Srs, anticorps serine racemase, anticorps Serine racemase, anticorps SRR, anticorps srr, anticorps NGR_b19540, anticorps ZPR_3642, anticorps MGYG_07950, anticorps Halhy_2637, anticorps Runsl_3290, anticorps Srr

Sujet: The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5' phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 38 kDa