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KIF1A anticorps (AA 902-1015)

KIF1A Reactivité: Souris, Rat WB, IF Hôte: Souris Monoclonal 16-KIF1A unconjugated
N° du produit ABIN968736
  • Antigène Voir toutes KIF1A Anticorps
    KIF1A (Kinesin Family Member 1A (KIF1A))
    Épitope
    • 9
    • 2
    • 1
    AA 902-1015
    Reactivité
    • 13
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 14
    • 1
    Souris
    Clonalité
    • 14
    • 1
    Monoclonal
    Conjugué
    • 8
    • 3
    • 2
    • 2
    Cet anticorp KIF1A est non-conjugé
    Application
    • 8
    • 6
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse KIF1A aa. 902-1015
    Clone
    16-KIF1A
    Isotype
    IgG1
    Top Product
    Discover our top product KIF1A Anticorps primaire
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Bloom: "The UNC-104/KIF1 family of kinesins." dans: Current opinion in cell biology, Vol. 13, Issue 1, pp. 36-40, (2001) (PubMed).

    Yonekawa, Harada, Okada, Funakoshi, Kanai, Takei, Terada, Noda, Hirokawa: "Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice." dans: The Journal of cell biology, Vol. 141, Issue 2, pp. 431-41, (1998) (PubMed).

    Okada, Yamazaki, Sekine-Aizawa, Hirokawa: "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors." dans: Cell, Vol. 81, Issue 5, pp. 769-80, (1995) (PubMed).

  • Antigène
    KIF1A (Kinesin Family Member 1A (KIF1A))
    Autre désignation
    KIF1A (KIF1A Produits)
    Synonymes
    anticorps ATSV, anticorps C630002N23Rik, anticorps Gm1626, anticorps Kns1, anticorps C2orf20, anticorps HSN2C, anticorps MRD9, anticorps SPG30, anticorps UNC104, anticorps kinesin family member 1A, anticorps kinesin family member 1Aa, anticorps KIF1A, anticorps kif1a, anticorps Kif1a, anticorps kif1aa
    Sujet
    The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF1A/1B, KIF3A/3B, KRP85/95, and Klp68d/64. KIF1A and KIF1B are 93% homologous in their N-terminal motor domains, however KIF1A contains a C-terminal PH domain. KIF1A and KIF1B are expressed in neurons where KIF1A is involved in fast anterograde axon transport of synaptic vesicles, and KIF1B is involved in anterograde axon transport of mitochondria. KIF1A associates with organelles that contain synaptotagmin, synaptophysin, and Rab3A. Disruption of the KIF1A gene in mice causes decreases in synaptic vesicle density, neuronal degeneration, and deficits in motor and sensory function. Thus, KIF1A is a critical brain motor protein involved with axonal transport of synaptic vesicle precursors. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    200 kDa
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