Calreticulin anticorps (AA 270-390)
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- Antigène Voir toutes Calreticulin (CALR) Anticorps
- Calreticulin (CALR)
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Épitope
- AA 270-390
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Calreticulin est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Réactivité croisée
- Humain, Rat (Rattus)
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Mouse Calreticulin aa. 270-390
- Clone
- 16-Calreticulin
- Isotype
- IgG1
- Top Product
- Discover our top product CALR Anticorps primaire
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- Commentaires
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Related Products: ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
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Calreticulin is directly involved in anti-alpha3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2." dans: Biochemical and biophysical research communications, Vol. 283, Issue 2, pp. 297-302, (2001) (PubMed).
: "Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins." dans: The EMBO journal, Vol. 18, Issue 23, pp. 6718-29, (2000) (PubMed).
: "Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 11, pp. 6426-32, (1999) (PubMed).
: "Determination of the sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a novel nested set method." dans: Gene, Vol. 120, Issue 2, pp. 217-25, (1992) (PubMed).
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Calreticulin is directly involved in anti-alpha3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2." dans: Biochemical and biophysical research communications, Vol. 283, Issue 2, pp. 297-302, (2001) (PubMed).
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- Antigène
- Calreticulin (CALR)
- Autre désignation
- Calreticulin (CALR Produits)
- Synonymes
- anticorps CRT, anticorps RO, anticorps SSA, anticorps cC1qR, anticorps crc, anticorps crt, anticorps Calregulin, anticorps CG9429, anticorps Clr, anticorps Dmel\\CG9429, anticorps anon-EST:Liang-2.11, anticorps anon-EST:Liang-2.17, anticorps anon-EST:fe3D7, anticorps clone 2.11, anticorps clone 2.17, anticorps eth, anticorps potp, anticorps cc1qr, anticorps ssa, anticorps NV19007, anticorps CRP55, anticorps ERp60, anticorps HACBP, anticorps CHOT1, anticorps CHT1, anticorps CT1, anticorps AA589632, anticorps CRTR, anticorps Creat, anticorps CCDS1, anticorps calrl2, anticorps fc66d10, anticorps wu:fc66d10, anticorps wu:fj50c03, anticorps zgc:66153, anticorps calreticulin, anticorps calreticulin L homeolog, anticorps Calreticulin, anticorps putative calreticulin, anticorps solute carrier family 6 member 8, anticorps solute carrier family 6 (neurotransmitter transporter, creatine), member 8, anticorps CALR, anticorps calr.L, anticorps Crt, anticorps crt, anticorps CRT, anticorps Calr, anticorps calr, anticorps LMJF_31_2600, anticorps Crc, anticorps Slc6a8, anticorps SLC6A8, anticorps LOC8269812
- Sujet
- Proteins undergo numerous modifications, including folding, translocation, and degradation. During such modifications, polypeptides are rarely in a native, stable state. Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through ATP-dependent folding. Many chaperone proteins are found in the endoplasmic reticulum (ER). Calreticulin is a luminal ER protein that is 39% homologous to the ER chaperone protein, calnexin. Calreticulin contains a C-terminal KDEL ER retention signal, and can bind Ca2+, Zn2+, ATP, and the proteins, ERp57 and protein disulfide isomerase. The molecular chaperone activities of calreticulin may include folding of both Asn-linked glycoproteins and non-glycosylated proteins. In addition, calreticulin is a component of MHC I/transporter associated with Ag presentation (TAP) complex where it may function in peptide assembly onto nascent class I molecules. Calreticulin may also function in integrin signaling, since it binds a3-integrin subunits and regulates integrin-mediated metalloprotease secretion. Thus, calreticulin may be involved in Ca2+ storage, cell adhesion, and protein folding. This antibody is routinely tested by western blot analysis.
- Poids moléculaire
- 60 kDa
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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