ARPC3 anticorps (AA 10-118)
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- Antigène Voir toutes ARPC3 Anticorps
- ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))
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Épitope
- AA 10-118
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Reactivité
- Humain, Souris, Rat, Chien, Poulet
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ARPC3 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Réactivité croisée
- Souris, Rat (Rattus), Poulet, Chien
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human p21-Arc aa. 10-118
- Clone
- 26-p21
- Isotype
- IgG1
- Top Product
- Discover our top product ARPC3 Anticorps primaire
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- Commentaires
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Related Products: ABIN968535, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
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Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." dans: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, (2001) (PubMed).
: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." dans: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, (1997) (PubMed).
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Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." dans: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, (2001) (PubMed).
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- Antigène
- ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))
- Autre désignation
- p21-Arc (ARPC3 Produits)
- Synonymes
- anticorps ARC21, anticorps p21-Arc, anticorps 1110006A04Rik, anticorps 21kDa, anticorps AA408672, anticorps AI788639, anticorps p21-Ar, anticorps p21Arc, anticorps arc21, anticorps p21-arc, anticorps zgc:86828, anticorps actin related protein 2/3 complex subunit 3, anticorps actin related protein 2/3 complex, subunit 3, anticorps actin related protein 2/3 complex subunit 3 L homeolog, anticorps actin related protein 2/3 complex, subunit 3, 21kDa, anticorps actin related protein 2/3 complex subunit 3 pseudogene, anticorps actin-related protein 2/3 complex subunit 3, anticorps actin-related protein 2/3 complex subunit 3 pseudogene, anticorps ARPC3, anticorps Arpc3, anticorps arpc3.L, anticorps LOC738738, anticorps arpc3, anticorps LOC100036831, anticorps LOC100341254
- Sujet
- Cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments occurs through the interactions between actin and actin binding proteins. Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Actin related proteins (Arp) 2/3 complex is an actin polymerization inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. The Arp2 and Arp3 subunits may nucleate actin polymerization, while the p41-Arc subunit is a WD repeat-containing protein that may regulate both the activity and localization of the Arp2/3 complex. Arp3, p34-Arc, and p21-Arc are localized to the lamellipodia of stationary and locomoting fibroblasts. Both WASP and Abp1p are acidic sequence-containing proteins that activate the Arp2/3 complex. However, WASP binds actin monomers, while the endocytosis-related Abp1p protein binds actin filaments. Thus, Arp2/3 complex may regulate actin polymerization in specific cell locations through interaction with actin binding Arp2/3 activators.
- Poids moléculaire
- 21 kDa
- Pathways
- Signalisation RTK, Regulation of Actin Filament Polymerization
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