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TOMM20 anticorps (AA 47-145)

TOMM20 Reactivité: Humain, Rat, Chien WB, IF Hôte: Souris Monoclonal 29-Tom20 unconjugated
N° du produit ABIN968798
  • Antigène Voir toutes TOMM20 Anticorps
    TOMM20 (Mitochondrial Import Receptor Subunit TOM20 homolog (TOMM20))
    Épitope
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 47-145
    Reactivité
    • 35
    • 28
    • 27
    • 1
    • 1
    Humain, Rat, Chien
    Hôte
    • 33
    • 2
    Souris
    Clonalité
    • 24
    • 11
    Monoclonal
    Conjugué
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp TOMM20 est non-conjugé
    Application
    • 17
    • 9
    • 9
    • 8
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Tom20 aa. 47-145
    Clone
    29-Tom20
    Isotype
    IgG1
    Top Product
    Discover our top product TOMM20 Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Krimmer, Rapaport, Ryan, Meisinger, Kassenbrock, Blachly-Dyson, Forte, Douglas, Neupert, Nargang, Pfanner: "Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex." dans: The Journal of cell biology, Vol. 152, Issue 2, pp. 289-300, (2001) (PubMed).

    Abe, Shodai, Muto, Mihara, Torii, Nishikawa, Endo, Kohda: "Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20." dans: Cell, Vol. 100, Issue 5, pp. 551-60, (2000) (PubMed).

    Hernández, Giner, Hernández-Yago: "Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes." dans: Gene, Vol. 239, Issue 2, pp. 283-91, (1999) (PubMed).

  • Antigène
    TOMM20 (Mitochondrial Import Receptor Subunit TOM20 homolog (TOMM20))
    Autre désignation
    Tom20 (TOMM20 Produits)
    Synonymes
    anticorps MAS20, anticorps MOM19, anticorps TOM20, anticorps 1810060K07Rik, anticorps BB284719, anticorps Gm19268, anticorps mKIAA0016, anticorps tomm20, anticorps wu:fk47b11, anticorps zgc:73165, anticorps mas20, anticorps mom19, anticorps tom20, anticorps zgc:92628, anticorps translocase of outer mitochondrial membrane 20, anticorps translocase of outer mitochondrial membrane 20 homolog (yeast), anticorps Mitochondrial import receptor subunit TOM20 homolog, anticorps translocase of outer mitochondrial membrane 20 homolog L homeolog, anticorps translocase of outer mitochondrial membrane 20b, anticorps TOMM20, anticorps Tomm20, anticorps tomm20a, anticorps tomm-20, anticorps tomm20.L, anticorps tomm20b
    Sujet
    Many mitochondrial proteins are encoded by nuclear genes and synthesized in the cytosol as pre-proteins. These pre-proteins are targeted to the mitochondria where they are translocated across the outer and inner membranes of the mitochondria. At the outer membrane of the mitochondria, this process requires a multiprotein complex called the Translocase of the Outer Membrane of the mitochondria (TOM). The TOM complex includes receptor components, Tom20, 22, 37, and 70, as well as a multisubunit general import pore complex of 400 kDa. Tom20 contains a hydrophobic N-terminal region that anchors it to the outer membrane of the mitochondria, and a cytosolic region that contains a domain that facilitates binding to the basic amphiphilic targeting sequences of pre-proteins and a tetratricopeptide repeat (TPR) motif involved in interactions with Tom70. In yeast, Tom20 and Tom22 mediate the import of all pre-proteins known to use the general import machinery of the mitochondria. Thus, Tom20 is an important receptor for many mitochondrial pre-proteins that use the outer mitochondrial translocation complex.
    Poids moléculaire
    18 kDa
    Pathways
    Unfolded Protein Response
Support technique