TCAP anticorps (AA 1-167)

N° du produit ABIN968822

Détail du produit anti-TCAP anticorps

Antigène: TCAP (Titin-Cap (Telethonin) (TCAP))

Épitope: AA 1-167

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TCAP est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse Telethonin aa. 1-167

Clone: 53-Telethonin

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-TCAP (ABIN968822)

Schröder, Reimann, Iakovenko, Mues, Bönnemann, Matten, Gautel: "Early and selective disappearance of telethonin protein from the sarcomere in neurogenic atrophy." dans: Journal of muscle research and cell motility, Vol. 22, Issue 3, pp. 259-64, (2001) (PubMed).

Moreira, Wiltshire, Faulkner, Nilforoushan, Vainzof, Suzuki, Valle, Reeves, Zatz, Passos-Bueno, Jenne: "Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin." dans: Nature genetics, Vol. 24, Issue 2, pp. 163-6, (2000) (PubMed).

Mason, Bayol, Loughna: "The novel sarcomeric protein telethonin exhibits developmental and functional regulation." dans: Biochemical and biophysical research communications, Vol. 257, Issue 3, pp. 699-703, (1999) (PubMed).

Valle, Faulkner, De Antoni, Pacchioni, Pallavicini, Pandolfo, Tiso, Toppo, Trevisan, Lanfranchi: "Telethonin, a novel sarcomeric protein of heart and skeletal muscle." dans: FEBS letters, Vol. 415, Issue 2, pp. 163-8, (1997) (PubMed).

Détails sur TCAP

Antigène: TCAP (Titin-Cap (Telethonin) (TCAP))

Autre désignation: Telethonin (TCAP Produits)

Synonymes: anticorps TCAP, anticorps CMD1N, anticorps LGMD2G, anticorps T-cap, anticorps TELE, anticorps telethonin, anticorps AI503981, anticorps AJ223855, anticorps titin-cap, anticorps titin-cap (telethonin), anticorps titin-cap S homeolog, anticorps TCAP, anticorps tcap, anticorps tcap.S, anticorps Tcap

Sujet: Autosomal recessive limb-girdle muscular dystrophy (AR LGMD), a genetically heterogeneous group of disorders affecting the proximal musculature, has eight distinct forms: 2A to 2H. Each of these forms is caused by specific gene mutations. A mutation in the telethonin gene causes LGMD 2G. Telethonin, a 19 kDa sarcomeric protein found in striated and cardiac muscle, has a developmentally and functionally regulated expression pattern. Telethonin transcript down-regulation occurs in response to muscle denervation. Protein levels of telethonin are partially regulated by neuronal activity, thereby linking telethonin to dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle. The telethonin transcript exhibits a pattern of accumulation typical of contractile proteins, suggesting a role for the protein in myofibrillar assembly. Immunofluorescence images show that telethonin co-localizes with myosin, which is an expression pattern typical of sarcomeric proteins. Telethonin has a known sarcomeric binding partner, titin, and is also known as titin CAP (TCAP). Therefore, telethonin plays a major role in AR LGMD 2G and is also important as a developmentally and functionally regulated sarcomeric protein.

Poids moléculaire: 19 kDa