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RIPK2 anticorps (AA 333-532)

RIPK2 Reactivité: Humain, Rat, Chien WB, IF Hôte: Souris Monoclonal 25-RIG unconjugated
N° du produit ABIN968828
  • Antigène Voir toutes RIPK2 Anticorps
    RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
    Épitope
    • 12
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 333-532
    Reactivité
    • 72
    • 39
    • 20
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Humain, Rat, Chien
    Hôte
    • 67
    • 6
    • 1
    Souris
    Clonalité
    • 69
    • 5
    Monoclonal
    Conjugué
    • 44
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RIPK2 est non-conjugé
    Application
    • 57
    • 36
    • 27
    • 10
    • 10
    • 7
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human RIP2/RICK aa. 333-532
    Clone
    25-RIG
    Isotype
    IgG1
    Top Product
    Discover our top product RIPK2 Anticorps primaire
  • Commentaires

    Related Products: ABIN968536, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Inohara, Koseki, Lin, del Peso, Lucas, Chen, Ogura, Núñez: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." dans: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, (2000) (PubMed).

    Navas, Baldwin, Stewart: "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase." dans: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33684-90, (1999) (PubMed).

  • Antigène
    RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
    Autre désignation
    RIP2/RICK (RIPK2 Produits)
    Synonymes
    anticorps RIPK2, anticorps 2210420D18Rik, anticorps CARD3, anticorps CARDIAK, anticorps CCK, anticorps D4Bwg0615e, anticorps RICK, anticorps RIP2, anticorps GIG30, anticorps receptor interacting serine/threonine kinase 2, anticorps receptor (TNFRSF)-interacting serine-threonine kinase 2, anticorps receptor-interacting serine-threonine kinase 2, anticorps RIPK2, anticorps Ripk2
    Sujet
    Members of the TNFR family (TNFRs, DRs, Fas, lymphotoxin-beta-receptor, CD40, CD30, and OX-40) regulate a variety of cellular responses, such as cell activation, proliferation, differentiation, NF-kappaB activation, and apoptosis. Signaling through TNFR family members involves several families of receptor-associated proteins. RIP and RIP2 (RICK/Cardiak) are ser/thr kinase adaptor molecules that associate with TNFR complexes. Both RIPs contain homologous N-teriminal ser/thr kinase domains, but RIP contains a C-terminal death domain, while RIP2 contains a C-terminal caspase activation and recruitment domain (CARD) similar to those found in IAPs. Both RIP and RIP2 can activate NF-kappaB and cause cell death. RIP2 is recruited to TNFRs through interactions with TRAF1, TRAF5, and TRAF6, and RIP2 activation of NF-kappaB requires IKKalpha, IKKbeta, and IKKgamma. In addition, RIP2 can be activated through interactions with Ras-activated Raf1, and RIP2 can activate ERK1 and ERK2. Thus, RIP proteins may regulate TNFR signaling through both ser/thr kinase activity and interaction with the apoptotic machinery.
    Poids moléculaire
    61 kDa
    Pathways
    TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
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