APOE anticorps

N° du produit ABIN968962

Détail du produit anti-APOE anticorps

Antigène: APOE (Apolipoprotein E (APOE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOE est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human ApoE expressed in E. coli.

Clone: 1H4

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-APOE (ABIN968962)

Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: "Apolipoprotein E gene polymorphism in psoriasis." dans: Archives of dermatological research, Vol. 301, Issue 6, pp. 405-10, (2009) (PubMed).

Zintzaras, Kitsios, Triposkiadis, Lau, Raman: "APOE gene polymorphisms and response to statin therapy." dans: The pharmacogenomics journal, Vol. 9, Issue 4, pp. 248-57, (2009) (PubMed).

Détails sur APOE

Antigène: APOE (Apolipoprotein E (APOE))

Autre désignation: ApoE (APOE Produits)

Synonymes: anticorps ad2, anticorps apoprotein, anticorps im:7036787, anticorps wu:fb69a05, anticorps zgc:110064, anticorps apoe, anticorps AI255918, anticorps AD2, anticorps LDLCQ5, anticorps LPG, anticorps APOEA, anticorps Apo-E, anticorps apolipoprotein E, anticorps apolipoprotein Ea, anticorps apoe, anticorps apoea, anticorps Apoe, anticorps APOE

Sujet:

Description: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20 % of very low density lipoproteins (VLDL) and 1-2 % of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

Aliases: AD2, LPG, LDLCQ5, MGC1571

Poids moléculaire: 36 kDa

ID gène: 348

HGNC: 348

Pathways: Regulation of Cell Size, Lipid Metabolism