B-Cell Linker anticorps

N° du produit ABIN968984

Détail du produit anti-B-Cell Linker anticorps

Antigène: B-Cell Linker (BLNK)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp B-Cell Linker est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: BLNK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human BLNK expressed in E. Coli.

Clone: 5G9

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-B-Cell Linker (ABIN968984)

Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." dans: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).

Kamino, Futamura, Nakamura, Kitamura, Kabu, Arakawa: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." dans: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).

Détails sur B-Cell Linker

Antigène: B-Cell Linker (BLNK)

Autre désignation: BLNK (BLNK Produits)

Synonymes: anticorps BLNK, anticorps blnk, anticorps MGC147045, anticorps BASH, anticorps Bca, anticorps Ly-57, anticorps Ly57, anticorps Lyw-57, anticorps SLP-65, anticorps AGM4, anticorps BLNK-S, anticorps LY57, anticorps SLP65, anticorps bca, anticorps B-cell linker, anticorps B cell linker, anticorps BLNK, anticorps blnk, anticorps Blnk

Sujet:

Description: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Aliases: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

Poids moléculaire: 68kDa

ID gène: 29760

HGNC: 29760

UniProt: Q8WV28

Pathways: BCR Signaling