BPTF anticorps

N° du produit ABIN968990

Détail du produit anti-BPTF anticorps

Antigène: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BPTF est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human BPTF expressed in E. coli.

Clone: 2F10

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-BPTF (ABIN968990)

Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." dans: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).

Barbe, Lundberg, Oksvold, Stenius, Lewin, Björling, Asplund, Pontén, Brismar, Uhlén, Andersson-Svahn: "Toward a confocal subcellular atlas of the human proteome." dans: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).

Détails sur BPTF

Antigène: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Autre désignation: BPTF (BPTF Produits)

Synonymes: anticorps FAC1, anticorps FALZ, anticorps NURF301, anticorps 9430093H17Rik, anticorps Falz, anticorps BPTF, anticorps bromodomain PHD finger transcription factor, anticorps nucleosome-remodeling factor subunit NURF301, anticorps fetal alzheimer antigen, falz, anticorps BPTF, anticorps Bptf, anticorps LOC5576547, anticorps CpipJ_CPIJ011285, anticorps bptf

Sujet:

Description: BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level) .Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

Aliases: FAC1, FALZ, NURF301, BPTF

Poids moléculaire: 338 kDa

ID gène: 2186

HGNC: 2186