CDK1 anticorps

N° du produit ABIN969034

Détail du produit anti-CDK1 anticorps

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: CDC2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of CDC2 expressed in E. Coli.

Clone: 8C5A7F10

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CDK1 (ABIN969034)

Meyer, Merkel, Brückl, Schellerer, Schildberg, Campean, Hohenberger, Croner: "Cdc2 as prognostic marker in stage UICC II colon carcinomas." dans: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 8, pp. 1466-73, (2009) (PubMed).

Tang, Wu, Guo, Hansen, Perry, Freel, Nutt, Jackson, Kornbluth: "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." dans: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3536-43, (2008) (PubMed).

Détails sur CDK1

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Autre désignation: CDC2 (CDK1 Produits)

Sujet:

Description: The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Aliases: CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1

Poids moléculaire: 34kDa

ID gène: 983

HGNC: 983

UniProt: P06493

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA